PMID- 24399969
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 4
DP  - 2013 Dec 25
TI  - Mechanisms tagging senescent red blood cells for clearance in healthy humans.
PG  - 387
LID - 10.3389/fphys.2013.00387 [doi]
LID - 387
AB  - This review focuses on the analysis and evaluation of the diverse senescence 
      markers suggested to prime red blood cells (RBC) for clearance in humans. These 
      tags develop in the course of biochemical and structural alterations accompanying 
      RBC aging, as the decrease of activities of multiple enzymes, the gradual 
      accumulation of oxidative damage, the loss of membrane in form of microvesicles, 
      the redistribution of ions and alterations in cell volume, density, and 
      deformability. The actual tags represent the penultimate galactosyl residues, 
      revealed by desialylation of glycophorins, or the aggregates of the anion 
      exchanger (band 3 protein) to which anti-galactose antibodies bind in the first 
      and anti-band 3 naturally occurring antibodies (NAbs) in the second case. While 
      anti-band 3 NAbs bind to the carbohydrate-free portion of band 3 aggregates in 
      healthy humans, induced anti-lactoferrin antibodies bind to the 
      carbohydrate-containing portion of band 3 and along with anti-band 3 NAbs may 
      accelerated clearance of senescent RBC in patients with anti-neutrophil 
      cytoplasmic antibodies (ANCA). Exoplasmically accessible phosphatidylserine (PS) 
      and the alterations in the interplay between CD47 on RBC and its receptor on 
      macrophages, signal regulatory protein alpha (SIRPalpha protein), were also 
      reported to induce erythrocyte clearance. We discuss the relevance of each 
      mechanism and analyze the strength of the data.
FAU - Lutz, Hans U
AU  - Lutz HU
AD  - Department of Biology, Institute of Biochemistry ETH Zurich, Zurich, Switzerland.
FAU - Bogdanova, Anna
AU  - Bogdanova A
AD  - Vetsuisse Faculty, Zurich Center for Integrative Human Physiology (ZIHP), 
      Institute of Veterinary Physiology, University of Zurich Zurich, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131225
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC3872327
OTO - NOTNLM
OT  - hemoglobin
OT  - human red blood cells
OT  - naturally occurring antibodies
OT  - oxidative stress
OT  - senescence
OT  - vesicles
OT  - volume
EDAT- 2014/01/09 06:00
MHDA- 2014/01/09 06:01
PMCR- 2013/12/25
CRDT- 2014/01/09 06:00
PHST- 2013/10/30 00:00 [received]
PHST- 2013/12/09 00:00 [accepted]
PHST- 2014/01/09 06:00 [entrez]
PHST- 2014/01/09 06:00 [pubmed]
PHST- 2014/01/09 06:01 [medline]
PHST- 2013/12/25 00:00 [pmc-release]
AID - 10.3389/fphys.2013.00387 [doi]
PST - epublish
SO  - Front Physiol. 2013 Dec 25;4:387. doi: 10.3389/fphys.2013.00387.