PMID- 24401238
OWN - NLM
STAT- MEDLINE
DCOM- 20140916
LR  - 20220223
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 232
IP  - 1
DP  - 2014 Jan
TI  - Associations of matrix metalloproteinase-9 and monocyte chemoattractant protein-1 
      concentrations with carotid atherosclerosis, based on measurements of plaque and 
      intima-media thickness.
PG  - 199-203
LID - S0021-9150(13)00691-6 [pii]
LID - 10.1016/j.atherosclerosis.2013.11.040 [doi]
AB  - PURPOSE: To examine associations of matrix metalloproteinase-9 (MMP-9) and 
      monocyte chemoattractant protein-1 (MCP-1) concentrations with the severity of 
      carotid atherosclerosis, based on measurements of carotid plaque and intima-media 
      thickness (IMT). METHODS: This cross-sectional study included 116 stroke-free 
      participants (45.7% males, 54.3% females; mean age, 64.73 +/- 14.53 years). Serum 
      MMP-9 and MCP-1 concentrations were measured, and plaque morphology, including 
      total plaque score (PS), plaque stability, and IMT, was assessed 
      ultrasonographically. Participants were grouped according to total PS (0, 1-2, >/= 
      3), plaque stability (no plaque, stable, unstable) and IMT tertiles (<0.8 mm, 
      0.8-1 mm, >1 mm). Multinomial logistic regression models were used to assess the 
      associations of MMP-9 and MCP-1 concentrations with plaque and IMT values after 
      adjusting for vascular risk factors. RESULTS: MMP-9 quartiles (vs. quartile 1) 
      were significantly associated with a greater prevalence of plaque instability 
      [Q2: odds ratio (OR) = 5.13, 95% confidence interval (CI) = 1.01-24.9, p = 0.042; 
      Q3: OR = 15.5, 95% CI = 3.1-78.1, p = 0.001; Q4: OR = 13.2, 95% CI = 2.7-64.97, p 
      = 0.001] and high total PS (Q3: OR = 10.02, 95% CI = 1.5-65.33, p = 0.016; Q4: OR 
      = 21.5, 95% CI = 3.5-132.1, p = 0.001). MCP-1 concentration was significantly 
      associated with IMT (OR = 22.94, 95% CI = 2.14-245.66, p = 0.01). CONCLUSIONS: 
      Elevated serum MMP-9 concentration was independently associated with high total 
      carotid artery PS, plaque instability, and large IMT value. MCP-1 concentration 
      was independently associated with IMT, but not with plaque morphology.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Tan, Changhong
AU  - Tan C
AD  - Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical 
      University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.
FAU - Liu, Yi
AU  - Liu Y
AD  - Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical 
      University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.
FAU - Li, Weina
AU  - Li W
AD  - Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical 
      University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.
FAU - Deng, Fen
AU  - Deng F
AD  - Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical 
      University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.
FAU - Liu, Xi
AU  - Liu X
AD  - Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical 
      University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical 
      University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.
FAU - Gui, Yuejiang
AU  - Gui Y
AD  - Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical 
      University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.
FAU - Qin, Lu
AU  - Qin L
AD  - Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical 
      University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.
FAU - Hu, Changlin
AU  - Hu C
AD  - Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical 
      University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.
FAU - Chen, Lifen
AU  - Chen L
AD  - Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical 
      University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China. 
      Electronic address: lifen_chen@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131125
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 268B43MJ25 (Uric Acid)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carotid Arteries/*diagnostic imaging
MH  - Carotid Artery Diseases/*blood/diagnostic imaging
MH  - *Carotid Intima-Media Thickness
MH  - Chemokine CCL2/*blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Matrix Metalloproteinase 9/*blood
MH  - Middle Aged
MH  - Odds Ratio
MH  - Plaque, Atherosclerotic/*blood
MH  - Prevalence
MH  - Regression Analysis
MH  - Risk Factors
MH  - Uric Acid/blood
OTO - NOTNLM
OT  - Carotid atherosclerosis
OT  - Intima-media thickness
OT  - Plaque score
OT  - Serum matrix metalloproteinase-9
OT  - Serum monocyte chemoattractant protein-1
EDAT- 2014/01/10 06:00
MHDA- 2014/09/17 06:00
CRDT- 2014/01/10 06:00
PHST- 2013/07/11 00:00 [received]
PHST- 2013/11/06 00:00 [revised]
PHST- 2013/11/06 00:00 [accepted]
PHST- 2014/01/10 06:00 [entrez]
PHST- 2014/01/10 06:00 [pubmed]
PHST- 2014/09/17 06:00 [medline]
AID - S0021-9150(13)00691-6 [pii]
AID - 10.1016/j.atherosclerosis.2013.11.040 [doi]
PST - ppublish
SO  - Atherosclerosis. 2014 Jan;232(1):199-203. doi: 
      10.1016/j.atherosclerosis.2013.11.040. Epub 2013 Nov 25.