PMID- 24401444
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20140109
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 119
DP  - 2014 Feb
TI  - Preparation of a novel porous poly (trimethylol propane triacrylate-co-ethylene 
      dimethacrylate) monolithic column for highly efficient HPLC separations of small 
      molecules.
PG  - 479-84
LID - S0039-9140(13)00938-7 [pii]
LID - 10.1016/j.talanta.2013.11.050 [doi]
AB  - A novel poly (trimethylol propane triacrylate-co-ethylene dimethacrylate) [poly 
      (TMPTA-co-EDMA)] monolith was prepared by in situ free-radical polymerization in 
      a 50 mm x 4.6mm i.d. stainless steel column and was investigated for high 
      performance liquid chromatography (HPLC). The porous structure of monolith was 
      optimized by changing the conditions of polymerization. The chemical group of the 
      monolithic column was confirmed by a Fourier transform infrared spectroscopy 
      (FT-IR) method and the morphology of column structure was characterized by 
      scanning electron microscopy (SEM). The mechanical strength and permeability were 
      also studied. Finally, a series of low-molecular-weight organic compounds were 
      utilized to evaluate the retention behaviors of the monolithic column. The result 
      demonstrated that the prepared column exhibited an RP-chromatographic behavior 
      and good separation performance. The method reproducibility was obtained by 
      evaluating the run-to-run and column-to-column with relative standard deviations 
      (RSDs) less than 0.7% (n=6) and 2.9% (n=6), respectively, which indicated that 
      prepared monolithic columns had good reproducibility and stability.
CI  - (c) 2013 Elsevier B.V. All rights reserved.
FAU - Bai, Xiaomei
AU  - Bai X
AD  - College of Pharmacy, Hebei University, Hebei Province Key Laboratory of 
      Pharmaceutical Quality Control, Baoding 071002, China.
FAU - Liu, Haiyan
AU  - Liu H
AD  - College of Pharmacy, Hebei University, Hebei Province Key Laboratory of 
      Pharmaceutical Quality Control, Baoding 071002, China. Electronic address: 
      lhy1610@126.com.
FAU - Wei, Dan
AU  - Wei D
AD  - College of Pharmacy, Hebei University, Hebei Province Key Laboratory of 
      Pharmaceutical Quality Control, Baoding 071002, China.
FAU - Yang, Gengliang
AU  - Yang G
AD  - College of Pharmacy, Hebei University, Hebei Province Key Laboratory of 
      Pharmaceutical Quality Control, Baoding 071002, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131125
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Acrylates)
RN  - 0 (Methacrylates)
RN  - 0 (Polymers)
RN  - 4B67KGL96S (trimethylolpropane triacrylate)
RN  - 7BK5G69305 (ethylene dimethacrylate)
SB  - IM
MH  - Acrylates/*chemistry
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Methacrylates/*chemistry
MH  - Microscopy, Electron, Scanning
MH  - Polymers/*chemistry
MH  - Reproducibility of Results
MH  - Spectroscopy, Fourier Transform Infrared
OTO - NOTNLM
OT  - High performance liquid chromatography
OT  - Low-molecular-weight organic compounds
OT  - Monolithic column
OT  - Trimethylol propane triacrylate
EDAT- 2014/01/10 06:00
MHDA- 2014/09/03 06:00
CRDT- 2014/01/10 06:00
PHST- 2013/08/08 00:00 [received]
PHST- 2013/11/14 00:00 [revised]
PHST- 2013/11/16 00:00 [accepted]
PHST- 2014/01/10 06:00 [entrez]
PHST- 2014/01/10 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
AID - S0039-9140(13)00938-7 [pii]
AID - 10.1016/j.talanta.2013.11.050 [doi]
PST - ppublish
SO  - Talanta. 2014 Feb;119:479-84. doi: 10.1016/j.talanta.2013.11.050. Epub 2013 Nov 
      25.