PMID- 24401942
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20211021
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Linking)
VI  - 34
IP  - 3
DP  - 2014 Apr
TI  - Piperine reverses chronic unpredictable mild stress-induced behavioral and 
      biochemical alterations in rats.
PG  - 403-8
LID - 10.1007/s10571-014-0025-1 [doi]
AB  - Previous studies in our laboratory have demonstrated that piperine produced 
      antidepressant-like action in various mouse models of behavioral despair, which 
      was related to the serotonergic system. The present study aimed to examine the 
      behavioral and biochemical effects of piperine in rats exposed to chronic 
      unpredictable mild stress (CUMS). The results showed that CUMS caused 
      depression-like behavior in rats, as indicated by the significant decrease in 
      sucrose consumption and increase in immobility time in the forced swim test. In 
      addition, it was found that serotonin (5-HT) and brain-derived neurotrophic 
      factor (BDNF) contents in the hippocampus and frontal cortex were significantly 
      decreased in CUMS-treated rats. Treating the animals with piperine significantly 
      suppressed behavioral and biochemical changes induced by CUMS. The results 
      suggest that piperine produces an antidepressant-like effect in CUMS-treated 
      rats, which is possibly mediated by increasing 5-HT and BDNF contents in 
      selective brain tissues.
FAU - Mao, Qing-Qiu
AU  - Mao QQ
AD  - School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., 
      Hong Kong.
FAU - Huang, Zhen
AU  - Huang Z
FAU - Zhong, Xiao-Ming
AU  - Zhong XM
FAU - Xian, Yan-Fang
AU  - Xian YF
FAU - Ip, Siu-Po
AU  - Ip SP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140109
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Alkaloids)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Benzodioxoles)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Piperidines)
RN  - 0 (Polyunsaturated Alkamides)
RN  - 333DO1RDJY (Serotonin)
RN  - U71XL721QK (piperine)
SB  - IM
MH  - Alkaloids/*therapeutic use
MH  - Animals
MH  - Antidepressive Agents/*therapeutic use
MH  - Benzodioxoles/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Chronic Disease
MH  - Male
MH  - Piperidines/*therapeutic use
MH  - Polyunsaturated Alkamides/*therapeutic use
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Stress, Psychological/*drug therapy/*metabolism/psychology
EDAT- 2014/01/10 06:00
MHDA- 2015/02/13 06:00
CRDT- 2014/01/10 06:00
PHST- 2013/09/15 00:00 [received]
PHST- 2014/01/01 00:00 [accepted]
PHST- 2014/01/10 06:00 [entrez]
PHST- 2014/01/10 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
AID - 10.1007/s10571-014-0025-1 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2014 Apr;34(3):403-8. doi: 10.1007/s10571-014-0025-1. Epub 
      2014 Jan 9.