PMID- 24402023
OWN - NLM
STAT- MEDLINE
DCOM- 20140616
LR  - 20190918
IS  - 1677-9487 (Electronic)
IS  - 0004-2730 (Linking)
VI  - 57
IP  - 9
DP  - 2013 Dec
TI  - The unusual association of Graves' disease, chronic spontaneous urticaria, and 
      premature ovarian failure: report of a case and HLA haplotype characterization.
PG  - 748-52
LID - S0004-27302013000900013 [pii]
AB  - Chronic spontaneous urticaria (CSU), defined as the occurrence of spontaneous 
      wheals for more than six weeks, has been associated with autoimmune diseases. 
      Herein, we report the unusual association of CSU, Graves' disease, and premature 
      ovarian failure. Human leukocyte antigen (HLA) studies were performed. A 
      36-year-old woman presented symptoms and signs of hyperthyroidism for three 
      months. In the same period, the patient complained of widespread urticarial 
      wheals, intensely itchy, and poorly responsive to therapy with antihistaminic 
      agents. Hyperthyroidism was confirmed biochemically, and treatment with 
      methimazole was started. As hyperthyroidism improved, a marked improvement in her 
      urticaria was also observed. However, the patient continued to complain of 
      amenorrhea. Endocrine evaluation, at the age 38, was consistent with premature 
      ovarian failure. This is the first report of coexistence of GD, CSU, and POF. The 
      genetic background of such unusual association is a specific combination of HLA.
FAU - Ruggeri, Rosaria Maddalena
AU  - Ruggeri RM
FAU - Vita, Giuseppe
AU  - Vita G
FAU - D'Angelo, Anna Grazia
AU  - D'Angelo AG
FAU - Quattrocchi, Paolina
AU  - Quattrocchi P
FAU - Certo, Rosaria
AU  - Certo R
FAU - Benvenga, Salvatore
AU  - Benvenga S
FAU - Cannavo, Salvatore
AU  - Cannavo S
FAU - Gangemi, Sebastiano
AU  - Gangemi S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Brazil
TA  - Arq Bras Endocrinol Metabol
JT  - Arquivos brasileiros de endocrinologia e metabologia
JID - 0403437
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Chronic Disease
MH  - Female
MH  - Graves Disease/*complications/immunology
MH  - HLA Antigens/*immunology
MH  - Haplotypes/*immunology
MH  - Humans
MH  - Primary Ovarian Insufficiency/*complications/immunology
MH  - Time Factors
MH  - Urticaria/*complications/immunology
EDAT- 2014/01/10 06:00
MHDA- 2014/06/17 06:00
CRDT- 2014/01/10 06:00
PHST- 2013/07/11 00:00 [received]
PHST- 2013/08/07 00:00 [accepted]
PHST- 2014/01/10 06:00 [entrez]
PHST- 2014/01/10 06:00 [pubmed]
PHST- 2014/06/17 06:00 [medline]
AID - S0004-27302013000900013 [pii]
AID - 10.1590/s0004-27302013000900013 [doi]
PST - ppublish
SO  - Arq Bras Endocrinol Metabol. 2013 Dec;57(9):748-52. doi: 
      10.1590/s0004-27302013000900013.