PMID- 24402218
OWN - NLM
STAT- MEDLINE
DCOM- 20140711
LR  - 20181218
IS  - 1809-452X (Electronic)
IS  - 1516-4446 (Linking)
VI  - 35
IP  - 4
DP  - 2013 Oct-Dec
TI  - Is disorganized schizophrenia a predictor of treatment resistance? Evidence from 
      an observational study.
PG  - 432-4
LID - S1516-44462013000400432 [pii]
LID - 10.1590/1516-4446-2013-1190 [doi]
AB  - OBJECTIVE: To investigate whether inpatients with disorganized schizophrenia are 
      more resistant to treatment. METHOD: Eighty-five inpatients were assessed at 
      admission and at discharge for schizophrenia subtype, symptom severity, and 
      treatment resistance criteria. RESULTS: Disorganized patients were significantly 
      more treatment-resistant than paranoid patients (60%, p = 0.001), and presented 
      worse scores on the Positive and Negative Syndrome Scale (PANSS), the Clinical 
      Global Impression Scale (CGI-S), and the Global Assessment of Functioning Scale 
      (GAF) (p < 0.001). Although the difference was not significant, 80% of 
      treatment-resistant patients with disorganized schizophrenia responded to 
      clozapine. CONCLUSION: Patients with the disorganized subtype of schizophrenia 
      should benefit from clozapine as a second-line agent.
FAU - Ortiz, Bruno Bertolucci
AU  - Ortiz BB
AD  - Schizophrenia Program, Universidade Federal de Sao Paulo (UNIFESP), Sao PauloSP, 
      Brazil.
FAU - Araujo Filho, Gerardo Maria de
AU  - Araujo Filho GM
AD  - Interdisciplinary Laboratory of Clinical Neurosciences, UNIFESP, Sao PauloSP, 
      Brazil.
FAU - Araripe Neto, Ary Gadelha de Alencar
AU  - Araripe Neto AG
AD  - Schizophrenia Program, Universidade Federal de Sao Paulo (UNIFESP), Sao PauloSP, 
      Brazil.
FAU - Medeiros, Daiane
AU  - Medeiros D
AD  - Department of Psychiatry, Hospital das Clinicas Luzia de Pinho Melo, Associacao 
      Paulista para o Desenvolvimento da Medicina (SPDM), Mogi das CruzesSP, Brazil.
FAU - Bressan, Rodrigo Affonseca
AU  - Bressan RA
AD  - Schizophrenia Program, Universidade Federal de Sao Paulo (UNIFESP), Sao PauloSP, 
      Brazil.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20131223
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
RN  - 0 (Antipsychotic Agents)
RN  - J60AR2IKIC (Clozapine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antipsychotic Agents/*therapeutic use
MH  - Child
MH  - Clozapine/*therapeutic use
MH  - *Drug Resistance
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia, Disorganized/*drug therapy
MH  - Schizophrenia, Paranoid/*drug therapy
MH  - Young Adult
EDAT- 2014/01/10 06:00
MHDA- 2014/07/12 06:00
CRDT- 2014/01/10 06:00
PHST- 2013/06/13 00:00 [received]
PHST- 2013/07/22 00:00 [accepted]
PHST- 2014/01/10 06:00 [entrez]
PHST- 2014/01/10 06:00 [pubmed]
PHST- 2014/07/12 06:00 [medline]
AID - S1516-44462013000400432 [pii]
AID - 10.1590/1516-4446-2013-1190 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2013 Oct-Dec;35(4):432-4. doi: 10.1590/1516-4446-2013-1190. 
      Epub 2013 Dec 23.