PMID- 24403377
OWN - NLM
STAT- MEDLINE
DCOM- 20140311
LR  - 20181203
IS  - 1479-6805 (Electronic)
IS  - 0022-0795 (Linking)
VI  - 220
IP  - 2
DP  - 2014 Feb
TI  - Nandrolone decanoate inhibits gluconeogenesis and decreases fasting glucose in 
      Wistar male rats.
PG  - 143-53
LID - 10.1530/JOE-13-0259 [doi]
AB  - The use of anabolic-androgenic steroids to improve physical performance or 
      appearance has increased notably. The doses used are 10- to 100- fold higher than 
      the therapeutic dose (TD), and this abuse can cause several side effects. Glucose 
      metabolism is significantly affected by anabolic-androgenic steroid abuse, but 
      studies about glycemic regulation during fasting are scarce. There are some 
      evidences showing that testosterone can antagonize glucocorticoids action, which 
      are crucial to glucose production during fasting. Thus, the aim of this study was 
      to determine the impact of supraphysiological doses (SDs) of nandrolone decanoate 
      (DECA) on rat glucose metabolism during fasting. Male Wistar rats were treated 
      with i.m. injections of vehicle, a low TD (0.016 mg/100 g b.w.-TD group) or a 
      high SD (1 mg/100 g b.w.-SD group) of DECA, once a week for 8 weeks. After 12 h 
      fasting, we evaluated glucose and pyruvate tolerance tests, liver glycogen 
      content, serum levels of gluconeogenic substrates, insulin and corticosterone, 
      glucose uptake and hexokinase (HK) activity in skeletal muscle, and the adrenal 
      catecholamine content. SD group had increased serum insulin levels and a blunted 
      response to insulin regarding glucose uptake in skeletal muscle. Fasting serum 
      glucose decreased significantly in SD group, as well as the pyruvate tolerance 
      test and liver glycogen content. Moreover, serum levels of glycerol were 
      increased in SD group. Our data indicate that SDs of DECA exert effects on 
      different regulatory points of glucose metabolism, resulting in defective 
      gluconeogenesis and decreased skeletal muscle glucose uptake in response to 
      insulin.
FAU - Frankenfeld, Stephan Pinheiro
AU  - Frankenfeld SP
AD  - Laboratory of Molecular Radiobiology, Institute of Biophysics Carlos Chagas 
      Filho, UFRJ, CCS Laboratory of Endocrine Physiology, Institute of Biophysics 
      Carlos Chagas Filho Laboratory of Exercise Biology, School of Physical Education 
      and Sports Laboratory of Bioenergetics, Institute of Medical Biochemistry, 
      Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 373, Block G - 
      Underground - Room G0-031, 21941-902 Rio de Janeiro, RJ, Brazil.
FAU - de Oliveira, Leonardo Pires
AU  - de Oliveira LP
FAU - Ignacio, Daniele Leao
AU  - Ignacio DL
FAU - Coelho, Raquel Guimaraes
AU  - Coelho RG
FAU - Mattos, Mariana Nigro
AU  - Mattos MN
FAU - Ferreira, Andrea Claudia Freitas
AU  - Ferreira AC
FAU - Carvalho, Denise Pires
AU  - Carvalho DP
FAU - Fortunato, Rodrigo Soares
AU  - Fortunato RS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140108
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (Blood Glucose)
RN  - 3XMK78S47O (Testosterone)
RN  - 6PG9VR430D (Nandrolone)
RN  - H45187T098 (Nandrolone Decanoate)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Blood Glucose/*drug effects/metabolism
MH  - Body Composition/drug effects
MH  - Down-Regulation/drug effects
MH  - Fasting/blood
MH  - Gluconeogenesis/*drug effects
MH  - Glucose/metabolism
MH  - Glucose Tolerance Test
MH  - Male
MH  - Nandrolone/*analogs & derivatives/pharmacology
MH  - Nandrolone Decanoate
MH  - Rats
MH  - Rats, Wistar
MH  - Testosterone/blood
OTO - NOTNLM
OT  - anabolic-androgenic steroids
OT  - gluconeogenesis
OT  - glucose
OT  - insulin
EDAT- 2014/01/10 06:00
MHDA- 2014/03/13 06:00
CRDT- 2014/01/10 06:00
PHST- 2014/01/10 06:00 [entrez]
PHST- 2014/01/10 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - 220/2/143 [pii]
AID - 10.1530/JOE-13-0259 [doi]
PST - epublish
SO  - J Endocrinol. 2014 Jan 8;220(2):143-53. doi: 10.1530/JOE-13-0259. Print 2014 Feb.