PMID- 24403524
OWN - NLM
STAT- MEDLINE
DCOM- 20141015
LR  - 20211021
IS  - 1556-679X (Electronic)
IS  - 1556-6811 (Print)
IS  - 1556-679X (Linking)
VI  - 21
IP  - 3
DP  - 2014 Mar
TI  - Comparison of four commercial one-dose porcine circovirus type 2 (PCV2) vaccines 
      administered to pigs challenged with PCV2 and porcine reproductive and 
      respiratory syndrome virus at 17 weeks postvaccination to control porcine 
      respiratory disease complex under Korean field conditions.
PG  - 399-406
LID - 10.1128/CVI.00768-13 [doi]
AB  - Under Korean field conditions, coinfection with porcine circovirus type 2 (PCV2) 
      and porcine reproductive and respiratory syndrome virus (PRRSV) is most commonly 
      observed in porcine respiratory disease complex (PRDC). Despite the wide use of 
      PCV2 vaccination, PRDC remains a serious respiratory problem. Thus, the objective 
      of this study was to determine and compare the efficacy of 4 one-dose PCV2 
      vaccines on 3-week-old pigs with an experimental PCV2-PRRSV challenge at 17 weeks 
      postvaccination. Regardless of which commercial PCV2 vaccine was used, the 
      vaccination of piglets at 3 weeks of age was efficacious against cochallenge of 
      PCV2 and PRRSV, on the basis of growth performance and PCV2-associated lesions. 
      However, the inactivated chimeric PCV1-2 and the PCV2 vaccines induced higher 
      PCV2-specific neutralizing antibody (NA) titers and PCV2-specific gamma 
      interferon-secreting cells and lower PCV2 viremia levels than the two PCV2 
      subunit vaccines. The vaccination of piglets against PCV2 at 3 weeks of age was 
      effective in reducing PCV2 viremia and PCV2-associated lesions during the 
      finishing period, which is an age at which pigs are frequently affected by PRDC 
      caused by coinfection with PCV2 and PRRSV under Korean field conditions.
FAU - Park, Changhoon
AU  - Park C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Seo, Hwi Won
AU  - Seo HW
FAU - Han, Kiwon
AU  - Han K
FAU - Chae, Chanhee
AU  - Chae C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140108
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Viral Vaccines)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
EIN - Clin Vaccine Immunol. 2014 Jul;21(7):1021
MH  - Animals
MH  - Antibodies, Neutralizing/blood
MH  - Antibodies, Viral/blood
MH  - Body Weight
MH  - Circoviridae Infections/pathology/prevention & control/*veterinary
MH  - Circovirus/*immunology
MH  - Coinfection/pathology/prevention & control/*veterinary
MH  - Interferon-gamma/metabolism
MH  - Korea
MH  - Leukocytes, Mononuclear/immunology
MH  - Porcine Reproductive and Respiratory Syndrome/pathology/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/immunology
MH  - Respiratory System/pathology
MH  - Swine
MH  - Swine Diseases/*prevention & control
MH  - Vaccination/methods
MH  - Viral Vaccines/*administration & dosage/*immunology
PMC - PMC3957680
EDAT- 2014/01/10 06:00
MHDA- 2014/10/16 06:00
PMCR- 2014/09/01
CRDT- 2014/01/10 06:00
PHST- 2014/01/10 06:00 [entrez]
PHST- 2014/01/10 06:00 [pubmed]
PHST- 2014/10/16 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - CVI.00768-13 [pii]
AID - 00768-13 [pii]
AID - 10.1128/CVI.00768-13 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2014 Mar;21(3):399-406. doi: 10.1128/CVI.00768-13. Epub 
      2014 Jan 8.