PMID- 24403596
OWN - NLM
STAT- MEDLINE
DCOM- 20141024
LR  - 20220330
IS  - 1535-9484 (Electronic)
IS  - 1535-9476 (Print)
IS  - 1535-9476 (Linking)
VI  - 13
IP  - 3
DP  - 2014 Mar
TI  - A protein profile of visceral adipose tissues linked to early pathogenesis of 
      type 2 diabetes mellitus.
PG  - 811-22
LID - 10.1074/mcp.M113.035501 [doi]
AB  - Adipose tissue is increasingly recognized as an endocrine organ playing important 
      pathophysiological roles in metabolic abnormalities, such as obesity, 
      cardiovascular disease, and type 2 diabetes mellitus (T2DM). In particular, 
      visceral adipose tissue (VAT), as opposed to subcutaneous adipose tissue, is 
      closely linked to the pathogenesis of insulin resistance and T2DM. Despite the 
      importance of VAT, its molecular signatures related to the pathogenesis of T2DM 
      have not been systematically explored. Here, we present comprehensive proteomic 
      analysis of VATs in drug-naive early T2DM patients and subjects with normal 
      glucose tolerance. A total of 4,707 proteins were identified in LC-MS/MS 
      experiments. Among them, 444 increased in abundance in T2DM and 328 decreased. 
      They are involved in T2DM-related processes including inflammatory responses, 
      peroxisome proliferator-activated receptor signaling, oxidative phosphorylation, 
      fatty acid oxidation, and glucose metabolism. Of these proteins, we selected 11 
      VAT proteins that can represent alteration in early T2DM patients. Among them, 
      up-regulation of FABP4, C1QA, S100A8, and SORBS1 and down-regulation of ACADL and 
      PLIN4 were confirmed in VAT samples of independent early T2DM patients using 
      Western blot. In summary, our profiling provided a comprehensive basis for 
      understanding the link of a protein profile of VAT to early pathogenesis of T2DM.
FAU - Kim, Su-Jin
AU  - Kim SJ
AD  - Department of Chemistry, Research Institute for Natural Sciences, Korea 
      University, Seoul, 136-701, Republic of Korea;
FAU - Chae, Sehyun
AU  - Chae S
FAU - Kim, Hokeun
AU  - Kim H
FAU - Mun, Dong-Gi
AU  - Mun DG
FAU - Back, Seunghoon
AU  - Back S
FAU - Choi, Hye Yeon
AU  - Choi HY
FAU - Park, Kyong Soo
AU  - Park KS
FAU - Hwang, Daehee
AU  - Hwang D
FAU - Choi, Sung Hee
AU  - Choi SH
FAU - Lee, Sang-Won
AU  - Lee SW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140108
PL  - United States
TA  - Mol Cell Proteomics
JT  - Molecular & cellular proteomics : MCP
JID - 101125647
RN  - 0 (Proteome)
SB  - IM
MH  - Chromatography, Liquid
MH  - Databases, Protein
MH  - Diabetes Mellitus, Type 2/*etiology/*metabolism/physiopathology
MH  - Humans
MH  - Intra-Abdominal Fat/*metabolism/pathology
MH  - Mass Spectrometry
MH  - Models, Biological
MH  - Molecular Weight
MH  - Proteome/*metabolism
MH  - Proteomics/*methods
MH  - Reproducibility of Results
MH  - Signal Transduction
PMC - PMC3945910
EDAT- 2014/01/10 06:00
MHDA- 2014/10/25 06:00
PMCR- 2015/03/01
CRDT- 2014/01/10 06:00
PHST- 2014/01/10 06:00 [entrez]
PHST- 2014/01/10 06:00 [pubmed]
PHST- 2014/10/25 06:00 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - S1535-9476(20)33392-2 [pii]
AID - M113.035501 [pii]
AID - 10.1074/mcp.M113.035501 [doi]
PST - ppublish
SO  - Mol Cell Proteomics. 2014 Mar;13(3):811-22. doi: 10.1074/mcp.M113.035501. Epub 
      2014 Jan 8.