PMID- 24404337
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140109
LR  - 20211021
IS  - 1976-9148 (Print)
IS  - 2005-4483 (Electronic)
IS  - 1976-9148 (Linking)
VI  - 21
IP  - 6
DP  - 2013 Nov
TI  - Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced 
      Learning and Memory Deficits in Mice.
PG  - 462-9
LID - 10.4062/biomolther.2013.074 [doi]
AB  - Eucommia ulmoides Oliv. Bark (EUE) is commonly used for the treatment of 
      hypertension, rheumatoid arthritis, lumbago, and ischialgia as well as to promote 
      longevity. In this study, we tested the effects of EUE aqueous extract in graded 
      doses to protect and enhance cognition in scopolamine-induced learning and memory 
      impairments in mice. EUE significantly improved the impairment of short-term or 
      working memory induced by scopolamine in the Y-maze and significantly reversed 
      learning and memory deficits in mice as measured by the passive avoidance and 
      Morris water maze tests. One day after the last trial session of the Morris water 
      maze test (probe trial session), EUE dramatically increased the latency time in 
      the target quadrant in a dose-dependent manner. Furthermore, EUE significantly 
      inhibited acetylcholinesterase (AChE) and thiobarbituric acid reactive substance 
      (TBARS) activities in the hippocampus and frontal cortex in a dose-dependent 
      manner. EUE also markedly increased brain-derived neurotrophic factor (BDNF) and 
      phosphorylation of cAMP element binding protein (CREB) in the hippocampus of 
      scopolamine-induced mice. Based on these findings, we suggest that EUE may be 
      useful for the treatment of cognitive deficits, and that the beneficial effects 
      of EUE are mediated, in part, by cholinergic signaling enhancement and/or 
      protection.
FAU - Kwon, Seung-Hwan
AU  - Kwon SH
AD  - Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 
      440-746, Republic of Korea.
FAU - Ma, Shi-Xun
AU  - Ma SX
AD  - Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 
      440-746, Republic of Korea.
FAU - Joo, Hyun-Joong
AU  - Joo HJ
AD  - Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 
      440-746, Republic of Korea.
FAU - Lee, Seok-Yong
AU  - Lee SY
AD  - Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 
      440-746, Republic of Korea.
FAU - Jang, Choon-Gon
AU  - Jang CG
AD  - Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 
      440-746, Republic of Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Biomol Ther (Seoul)
JT  - Biomolecules & therapeutics
JID - 101472832
PMC - PMC3879918
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Brain-derived neurotrophic factor
OT  - Eucommia ulmoides Oliv. Bark
OT  - Learning and memory
OT  - Scopolamine
OT  - cAMP element binding protein
EDAT- 2014/01/10 06:00
MHDA- 2014/01/10 06:01
PMCR- 2013/11/01
CRDT- 2014/01/10 06:00
PHST- 2013/09/13 00:00 [received]
PHST- 2013/10/30 00:00 [revised]
PHST- 2013/11/05 00:00 [accepted]
PHST- 2014/01/10 06:00 [entrez]
PHST- 2014/01/10 06:00 [pubmed]
PHST- 2014/01/10 06:01 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - ooomb4-21-462 [pii]
AID - 10.4062/biomolther.2013.074 [doi]
PST - ppublish
SO  - Biomol Ther (Seoul). 2013 Nov;21(6):462-9. doi: 10.4062/biomolther.2013.074.