PMID- 24404967
OWN - NLM
STAT- MEDLINE
DCOM- 20140502
LR  - 20181202
IS  - 1933-0715 (Electronic)
IS  - 1933-0707 (Linking)
VI  - 13
IP  - 3
DP  - 2014 Mar
TI  - Prenatal latex sensitization in patients with spina bifida: a pilot study.
PG  - 291-4
LID - 10.3171/2013.12.PEDS13402 [doi]
AB  - OBJECT: Patients with spina bifida are particularly vulnerable to developing 
      immunoglobulin E (IgE)-mediated latex sensitization. Even though many risk 
      factors leading to latex allergy in these patients have been described, it is 
      still unclear whether the increased prevalence of latex sensitization is disease 
      associated or due to the procedures used to treat spina bifida. The aim of this 
      study was to assess prenatal latex sensitization in patients with spina bifida by 
      examining IgE levels in umbilical cord blood. METHODS: Patients with spina bifida 
      and matched healthy infants were recruited from the University Medical Center 
      Hamburg-Eppendorf and Children's Hospital Altona. Latex-specific and total IgE 
      were assessed in umbilical cord blood using ImmunoCAP testing to evaluate the 
      degree of prenatal latex sensitization. RESULTS: Twenty-two subjects, 10 with 
      spina bifida and 12 healthy individuals, were included. Subjects were selected 
      after matching for sex, gestational age, weight, parental allergy profile, number 
      of prenatal examinations, and utilization of latex tools during pregnancy 
      (propensity score estimates, p = 0.36). In patients with spina bifida, 
      latex-specific and total IgE levels were significantly higher than those in 
      healthy individuals (p = 0.001). After normalization to total IgE, latex-specific 
      IgE levels were higher, yet not significantly increased (p = 0.085). CONCLUSIONS: 
      Perinatally, there is a significant augmentation of total and latex-specific IgE 
      in patients with spina bifida. After correcting for total IgE, latex-specific IgE 
      was increased, yet not significantly higher than in matched, healthy controls. 
      This pilot study gives novel insights in the immunological reactions related to 
      spina bifida. The increased latex-specific IgE levels could possibly be 
      associated with the occurrence of a latex allergy in the future.
FAU - Boettcher, Michael
AU  - Boettcher M
AD  - Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf and 
      Children's Hospital Altona;
FAU - Goettler, Susanne
AU  - Goettler S
FAU - Eschenburg, Georg
AU  - Eschenburg G
FAU - Kracht, Thorben
AU  - Kracht T
FAU - Kunkel, Philip
AU  - Kunkel P
FAU - Von der Wense, Axel
AU  - Von der Wense A
FAU - Reinshagen, Konrad
AU  - Reinshagen K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20140103
PL  - United States
TA  - J Neurosurg Pediatr
JT  - Journal of neurosurgery. Pediatrics
JID - 101463759
RN  - 0 (Latex)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fetal Blood/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Infant
MH  - Infant, Newborn
MH  - Latex/*adverse effects/*immunology
MH  - Latex Hypersensitivity/complications/etiology/*immunology
MH  - Male
MH  - Pilot Projects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*immunology
MH  - Risk Factors
MH  - Spinal Dysraphism/complications/*immunology
EDAT- 2014/01/11 06:00
MHDA- 2014/05/03 06:00
CRDT- 2014/01/11 06:00
PHST- 2014/01/11 06:00 [entrez]
PHST- 2014/01/11 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - 10.3171/2013.12.PEDS13402 [doi]
PST - ppublish
SO  - J Neurosurg Pediatr. 2014 Mar;13(3):291-4. doi: 10.3171/2013.12.PEDS13402. Epub 
      2014 Jan 3.