PMID- 24405043
OWN - NLM
STAT- MEDLINE
DCOM- 20141216
LR  - 20140210
IS  - 1526-4602 (Electronic)
IS  - 1525-7797 (Linking)
VI  - 15
IP  - 2
DP  - 2014 Feb 10
TI  - Uniaxially aligned electrospun all-cellulose nanocomposite nanofibers reinforced 
      with cellulose nanocrystals: scaffold for tissue engineering.
PG  - 618-27
LID - 10.1021/bm401656a [doi]
AB  - Uniaxially aligned cellulose nanofibers with well oriented cellulose nanocrystals 
      (CNCs) embedded were fabricated via electrospinning using a rotating drum as the 
      collector. Scanning electron microscope (SEM) images indicated that most 
      cellulose nanofibers were uniaxially aligned. The incorporation of CNCs into the 
      spinning dope resulted in more uniform morphology of the electrospun 
      cellulose/CNCs nanocomposite nanofibers (ECCNN). Polarized light microscope (PLM) 
      and transmission electron microscope (TEM) showed that CNCs dispersed well in 
      ECCNN nonwovens and achieved considerable orientation along the long axis 
      direction. This unique hierarchical microstructure of ECCNN nonwovens gave rise 
      to remarkable enhancement of their physical properties. By incorporating 20% 
      loading (in weight) of CNCs, the tensile strength and elastic modulus of ECCNN 
      along the fiber alignment direction were increased by 101.7 and 171.6%, 
      respectively. Their thermal stability was significantly improved as well. In 
      addition, the ECCNN nonwovens were assessed as potential scaffold materials for 
      tissue engineering. It was elucidated from MTT tests that the ECCNN were 
      essentially nontoxic to human cells. Cell culture experiments demonstrated that 
      cells could proliferate rapidly not only on the surface but also deep inside the 
      ECCNN. More importantly, the aligned nanofibers of ECCNN exhibited a strong 
      effect on directing cellular organization. This feature made the scaffold 
      particularly useful for various artificial tissues or organs, such as blood 
      vessel, tendon, nerve, and so on, in which cell orientation was crucial for their 
      performance.
FAU - He, Xu
AU  - He X
AD  - State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute 
      at Sichuan University , Chengdu 610065, China.
FAU - Xiao, Qiang
AU  - Xiao Q
FAU - Lu, Canhui
AU  - Lu C
FAU - Wang, Yaru
AU  - Wang Y
FAU - Zhang, Xiaofang
AU  - Zhang X
FAU - Zhao, Jiangqi
AU  - Zhao J
FAU - Zhang, Wei
AU  - Zhang W
FAU - Zhang, Ximu
AU  - Zhang X
FAU - Deng, Yulin
AU  - Deng Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140124
PL  - United States
TA  - Biomacromolecules
JT  - Biomacromolecules
JID - 100892849
RN  - 9004-34-6 (Cellulose)
SB  - IM
MH  - Cell Proliferation
MH  - Cell Survival
MH  - Cells, Cultured
MH  - Cellulose/*chemistry
MH  - Dental Sac/chemistry/cytology
MH  - Humans
MH  - Nanofibers/*chemistry
MH  - Nanoparticles/*chemistry
MH  - *Tissue Engineering
MH  - *Tissue Scaffolds
EDAT- 2014/01/11 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/01/11 06:00
PHST- 2014/01/11 06:00 [entrez]
PHST- 2014/01/11 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - 10.1021/bm401656a [doi]
PST - ppublish
SO  - Biomacromolecules. 2014 Feb 10;15(2):618-27. doi: 10.1021/bm401656a. Epub 2014 
      Jan 24.