PMID- 24405442
OWN - NLM
STAT- MEDLINE
DCOM- 20141024
LR  - 20140227
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 83
IP  - 3
DP  - 2014 Mar
TI  - Allele and haplotype frequencies of HLA-DPA1 and -DPB1 in the population of 
      Guadeloupe.
PG  - 147-53
LID - 10.1111/tan.12271 [doi]
AB  - Genetic polymorphism of human leukocyte antigen (HLA)-DPA1 and -DPB1 loci was 
      studied in 154 unrelated individuals from Guadeloupe, an archipelago of five 
      islands located in the Carribean Sea. Thirty different DPB1 and eight different 
      DPA1 alleles were observed with a heterozygosity index of 0.87 and 0.78, 
      respectively. This high degree of heterozygosity corresponds with those found in 
      African populations. The DPB1* 01:01:01 allele was most frequent (0.260), 
      followed by 02:01:02 (0.143) and 04:01:01 (0.127). The DPA1 alleles 01:03 
      (0.380), 02:01 (0.302), 02:02 (0.175) and 03:01 (0.123) were identified in >35 
      individuals each, whereas 01:04, 01:05 and 04:01 were present only once. 
      Haplotype estimations revealed the presence of 39 different haplotypes, with 
      DPB1*01:01:01-DPA1*02:02 and DPB1*02:01:02-DPA1*01:03 as the most frequent (0.143 
      and 0.140, respectively). A striking difference was observed in DPB1/DPA1 
      associations between DPB1*04:02 and *105:01, that have identical exon 2 
      sequences. DPB1*04:02 was exclusively associated with DPA1*01:03, whereas 
      DPB1*105:01 was present with DPA1*03:01, *03:02 or *04:01. This implies that the 
      DP molecules are actually different, and this difference is relevant to consider 
      in studies on the function of HLA-DP molecules in transplantation. Overall, 
      HLA-DPA1 and DPB1 allele frequencies and haplotypes of the population of 
      Guadeloupe were most similar to African populations, with characteristic alleles 
      and haplotypes that bespeaks the admixture with other ethnicities.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Voorter, C E M
AU  - Voorter CE
AD  - Transplantation Immunology, Tissue Typing Laboratory, Maastricht University 
      Medical Center, Maastricht, the Netherlands.
FAU - Groeneweg, M
AU  - Groeneweg M
FAU - Joannis, M-O
AU  - Joannis MO
FAU - Meertens, C
AU  - Meertens C
FAU - Agis, F
AU  - Agis F
FAU - Tilanus, M G J
AU  - Tilanus MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140110
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Epitopes)
RN  - 0 (HLA-DP alpha-Chains)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPA1 antigen)
RN  - 0 (HLA-DPB1 antigen)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Amino Acid Motifs
MH  - Child, Preschool
MH  - Epitopes/chemistry/immunology
MH  - Female
MH  - Gene Frequency/*genetics
MH  - *Genetics, Population
MH  - Guadeloupe
MH  - HLA-DP alpha-Chains/*genetics
MH  - HLA-DP beta-Chains/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Male
OTO - NOTNLM
OT  - Guadeloupe
OT  - HLA allele frequencies
OT  - HLA haplotypes
OT  - HLA-DPA1
OT  - HLA-DPB1
OT  - population
EDAT- 2014/01/11 06:00
MHDA- 2014/10/25 06:00
CRDT- 2014/01/11 06:00
PHST- 2013/09/06 00:00 [received]
PHST- 2013/11/15 00:00 [revised]
PHST- 2013/11/28 00:00 [accepted]
PHST- 2014/01/11 06:00 [entrez]
PHST- 2014/01/11 06:00 [pubmed]
PHST- 2014/10/25 06:00 [medline]
AID - 10.1111/tan.12271 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Mar;83(3):147-53. doi: 10.1111/tan.12271. Epub 2014 Jan 10.