PMID- 24405689
OWN - NLM
STAT- MEDLINE
DCOM- 20141201
LR  - 20171116
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 17
IP  - 5
DP  - 2014 May
TI  - Effects of curcumin on chronic, unpredictable, mild, stress-induced 
      depressive-like behaviour and structural plasticity in the lateral amygdala of 
      rats.
PG  - 793-806
LID - 10.1017/S1461145713001661 [doi]
AB  - Depression is a neuropsychiatric disease associated with wide ranging disruptions 
      in neuronal plasticity throughout the brain. Curcumin, a natural polyphenolic 
      compound of curcuma loga, has been demonstrated to be effective in the treatment 
      of depressive-like disorders. The present study aimed to investigate the 
      mechanisms underlying the antidepressant-like effects of curcumin in a rat model 
      of chronic, unpredictable, mild, stress (CUMS) -induced depression. The results 
      showed that CUMS produced depressive-like behaviours in rats, which were 
      associated with ultra-structural changes in neurons within the lateral amygdala 
      (LA). In addition, the expression of synapse-associated proteins such as 
      brain-derived neurotrophic factor (BDNF), PSD-95 and synaptophysin were 
      significantly decreased in the LA of CUMS-treated rats. Chronic administration of 
      curcumin (40 mg/kg, i.p. 6 wk) before stress exposure significantly prevented 
      these neuronal and biochemical alterations induced by CUMS, and suppressed 
      depressive-like behaviours, suggesting that this neuronal dysregulation may be 
      related to the depressive-like behaviours caused by CUMS. Together with our 
      previous results, the current findings demonstrate that curcumin exhibits 
      neuroprotection and antidepressant-like effects in the CUMS-induced depression 
      model. Furthermore, this antidepressant-like action of curcumin appears to be 
      mediated by modulating synapse-associated proteins within the LA. These findings 
      provide new insights into the underlying mechanisms leading to neural dysfunction 
      in depression and reveal the therapeutic potential for curcumin use in clinical 
      trials.
FAU - Zhang, Lin
AU  - Zhang L
AD  - Department of Physiology, Shandong University, School of Medicine, Wenhuaxilu 
      Road, Jinan, Shandong Province, 250012, PR, China.
FAU - Luo, Junxia
AU  - Luo J
AD  - Department of Physiology, Shandong University, School of Medicine, Wenhuaxilu 
      Road, Jinan, Shandong Province, 250012, PR, China.
FAU - Zhang, Minghua
AU  - Zhang M
AD  - Department of Physiology, Shandong University, School of Medicine, Wenhuaxilu 
      Road, Jinan, Shandong Province, 250012, PR, China.
FAU - Yao, Wei
AU  - Yao W
AD  - Department of Physiology, Shandong University, School of Medicine, Wenhuaxilu 
      Road, Jinan, Shandong Province, 250012, PR, China.
FAU - Ma, Xuelian
AU  - Ma X
AD  - Department of Physiology, Shandong University, School of Medicine, Wenhuaxilu 
      Road, Jinan, Shandong Province, 250012, PR, China.
FAU - Yu, Shu Yan
AU  - Yu SY
AD  - Department of Physiology, Shandong University, School of Medicine, Wenhuaxilu 
      Road, Jinan, Shandong Province, 250012, PR, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140109
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dietary Sucrose)
RN  - 0 (Disks Large Homolog 4 Protein)
RN  - 0 (Dlg4 protein, rat)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Synaptophysin)
RN  - 0 (Syp protein, rat)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Amygdala/*drug effects/physiopathology/ultrastructure
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Chronic Disease
MH  - Curcumin/*pharmacology
MH  - Depressive Disorder/*drug therapy/etiology/pathology/physiopathology
MH  - Dietary Sucrose
MH  - Disks Large Homolog 4 Protein
MH  - Drinking/drug effects
MH  - Exploratory Behavior/drug effects
MH  - Intracellular Signaling Peptides and Proteins/metabolism
MH  - Male
MH  - Membrane Proteins/metabolism
MH  - Motivation/drug effects
MH  - Motor Activity/drug effects
MH  - Neuronal Plasticity/*drug effects
MH  - Neurons/drug effects/physiology/ultrastructure
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/*complications
MH  - Synaptophysin/metabolism
MH  - Uncertainty
EDAT- 2014/01/11 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/11 06:00
PHST- 2014/01/11 06:00 [entrez]
PHST- 2014/01/11 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S1461145713001661 [pii]
AID - 10.1017/S1461145713001661 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2014 May;17(5):793-806. doi: 
      10.1017/S1461145713001661. Epub 2014 Jan 9.