PMID- 24406218
OWN - NLM
STAT- MEDLINE
DCOM- 20140926
LR  - 20211203
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 35
IP  - 9
DP  - 2014 Mar
TI  - Nanofibrous scaffolds releasing a small molecule BDNF-mimetic for the 
      re-direction of endogenous neuroblast migration in the brain.
PG  - 2692-712
LID - S0142-9612(13)01500-7 [pii]
LID - 10.1016/j.biomaterials.2013.12.016 [doi]
AB  - Brain tissue engineering has the potential to harness existing elements of 
      neurogenesis within the adult brain to overcome a microenvironment that is 
      otherwise inhibitory to regeneration, especially following severe tissue damage. 
      This study investigates the ability of electrospun poly epsilon-caprolactone (PCL) to 
      re-direct the migratory pathway of endogenous neuroblasts from the disrupted 
      subventricular zone (SVZ). A small molecule non-peptide ligand (BDNF-mimetic) 
      that mimicked the trophic properties of brain-derived neurotrophic factor (BDNF) 
      was incorporated into electrospun PCL scaffolds to improve neuroblast survival 
      and promote neuroblast migration towards the implant. PCL scaffolds were able to 
      support neuroblast infiltration and migration along the implant tract. In the 
      presence of the BDNF-mimetic, neuroblasts were able to migrate towards the 
      implant via the parenchyma, and their persistence within the implants was 
      prolonged. In addition, the BDNF-mimetic improved implant integration and 
      increased local neuronal plasticity by increasing neurite sprouting at the 
      tissue-implant interface. SMI32+ neurites were observed inside scaffolds at 21 
      days but not 8 days post implantation, indicating that at least some of the 
      infiltrated neuroblasts had differentiated into neurons.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Fon, Deniece
AU  - Fon D
AD  - Department of Materials Engineering, Monash University, Clayton, VIC 3800, 
      Australia; Florey Institute of Neuroscience and Mental Health, The University of 
      Melbourne, Parkville, VIC 3010, Australia.
FAU - Zhou, Kun
AU  - Zhou K
AD  - Department of Materials Engineering, Monash University, Clayton, VIC 3800, 
      Australia.
FAU - Ercole, Francesca
AU  - Ercole F
AD  - Department of Materials Engineering, Monash University, Clayton, VIC 3800, 
      Australia.
FAU - Fehr, Friederike
AU  - Fehr F
AD  - CSIRO Materials Science and Engineering, Clayton, VIC 3053, Australia.
FAU - Marchesan, Silvia
AU  - Marchesan S
AD  - CSIRO Materials Science and Engineering, Clayton, VIC 3053, Australia.
FAU - Minter, Myles R
AU  - Minter MR
AD  - Department of Pharmacology and Therapeutics, The University of Melbourne, 
      Parkville, VIC 3010, Australia.
FAU - Crack, Peter J
AU  - Crack PJ
AD  - Department of Pharmacology and Therapeutics, The University of Melbourne, 
      Parkville, VIC 3010, Australia.
FAU - Finkelstein, David I
AU  - Finkelstein DI
AD  - Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 
      Parkville, VIC 3010, Australia. Electronic address: d.finkelstein@florey.edu.au.
FAU - Forsythe, John S
AU  - Forsythe JS
AD  - Department of Materials Engineering, Monash University, Clayton, VIC 3800, 
      Australia. Electronic address: john.forsythe@monash.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140107
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Polyesters)
RN  - 24980-41-4 (polycaprolactone)
SB  - IM
MH  - Animals
MH  - Astrocytes/pathology
MH  - Biomimetic Materials/*pharmacology
MH  - Brain/*pathology
MH  - Brain-Derived Neurotrophic Factor/*chemistry
MH  - Cell Differentiation/drug effects
MH  - Cell Movement/*drug effects
MH  - Doublecortin Domain Proteins
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Gliosis/pathology
MH  - Implants, Experimental
MH  - Inflammation/pathology
MH  - Male
MH  - Microglia/pathology
MH  - Microtubule-Associated Proteins/metabolism
MH  - Nanofibers/*chemistry/ultrastructure
MH  - Neurites/drug effects/metabolism
MH  - Neurons/drug effects/metabolism/*pathology
MH  - Neuropeptides/metabolism
MH  - Polyesters/chemistry
MH  - Rats
MH  - Rats, Wistar
MH  - Tissue Scaffolds/*chemistry
OTO - NOTNLM
OT  - BDNF-mimetic
OT  - Brain repair
OT  - Neural tissue engineering
OT  - Neuroblast migration
OT  - PCL scaffold
OT  - Subventricular zone
EDAT- 2014/01/11 06:00
MHDA- 2014/09/27 06:00
CRDT- 2014/01/11 06:00
PHST- 2013/12/10 00:00 [received]
PHST- 2013/12/10 00:00 [accepted]
PHST- 2014/01/11 06:00 [entrez]
PHST- 2014/01/11 06:00 [pubmed]
PHST- 2014/09/27 06:00 [medline]
AID - S0142-9612(13)01500-7 [pii]
AID - 10.1016/j.biomaterials.2013.12.016 [doi]
PST - ppublish
SO  - Biomaterials. 2014 Mar;35(9):2692-712. doi: 10.1016/j.biomaterials.2013.12.016. 
      Epub 2014 Jan 7.