PMID- 24406738
OWN - NLM
STAT- MEDLINE
DCOM- 20141027
LR  - 20140307
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 20
DP  - 2014 Mar
TI  - Increased levels of neurotrophins in the cerebrospinal fluid of children with 
      Epstein-Barr virus meningoencephalitis.
PG  - 52-7
LID - S1201-9712(13)00359-7 [pii]
LID - 10.1016/j.ijid.2013.11.006 [doi]
AB  - OBJECTIVE: The aim of this study was to evaluate the expression of nerve growth 
      factor (NGF) and brain-derived neurotrophic factor (BDNF) in the cerebrospinal 
      fluid (CSF) of children with Epstein-Barr virus (EBV)-induced meningoencephalitis 
      (ME) in order to establish a possible correlation with laboratory findings and 
      neurological manifestations. METHODS: A prospective observational clinical study 
      was performed on 10 children with viral ME, five of them with EBV-induced ME. As 
      controls, we used CSF samples collected from children admitted with febrile 
      seizures. Neurotrophin levels were measured using an enzyme immunoassay. RESULTS: 
      Significantly higher levels of BDNF and NGF were detected in all patients with 
      viral ME compared to controls. Moreover, in patients with EBV-induced ME, the 
      neurotrophin levels were higher than in those with other viral ME. Of note, in 
      children with EBV-induced ME, we found a significant correlation between 
      neurotrophic factor levels and the number of lymphocytes in the CSF (p<0.001). In 
      these patients we also found a significant correlation between BDNF expression 
      and the blood platelet count (p<0.001). Interestingly, two patients with 
      EBV-induced ME showed a correlation between neurotrophin increase and persistent 
      brain abnormalities, such as prolonged alteration of mental status, psychomotor 
      agitation, and athetosis. CONCLUSIONS: Viral ME induces an early and strong 
      increased biosynthesis of neurotrophic factors. This neurotrophin over-expression 
      is likely to play a key role in the mechanisms of neuronal inflammation and in 
      the severity of brain damage, particularly in EBV-induced ME.
CI  - Copyright (c) 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Chiaretti, Antonio
AU  - Chiaretti A
AD  - Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli 
      Hospital, Largo Gemelli, I-00168 Rome, Italy. Electronic address: 
      achiaretti@yahoo.it.
FAU - Capozzi, Domenico
AU  - Capozzi D
AD  - Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli 
      Hospital, Largo Gemelli, I-00168 Rome, Italy.
FAU - Mariotti, Paolo
AU  - Mariotti P
AD  - Pediatric Neurology, Catholic University of the Sacred Heart, A. Gemelli 
      Hospital, Rome, Italy.
FAU - Valentini, Piero
AU  - Valentini P
AD  - Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli 
      Hospital, Largo Gemelli, I-00168 Rome, Italy.
FAU - Manni, Luigi
AU  - Manni L
AD  - Institute of Translational Pharmacology, CNR, Rome, Italy.
FAU - Buonsenso, Danilo
AU  - Buonsenso D
AD  - Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli 
      Hospital, Largo Gemelli, I-00168 Rome, Italy.
FAU - Fantacci, Claudia
AU  - Fantacci C
AD  - Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli 
      Hospital, Largo Gemelli, I-00168 Rome, Italy.
FAU - Ferrara, Pietro
AU  - Ferrara P
AD  - Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli 
      Hospital, Largo Gemelli, I-00168 Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20140107
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Brain/pathology/virology
MH  - Brain-Derived Neurotrophic Factor/*cerebrospinal fluid
MH  - Child, Preschool
MH  - Dose-Response Relationship, Drug
MH  - Epstein-Barr Virus Infections/*drug therapy
MH  - Female
MH  - Herpesvirus 4, Human/drug effects/isolation & purification
MH  - Humans
MH  - Infant
MH  - Male
MH  - Meningoencephalitis/*drug therapy/virology
MH  - Nerve Growth Factor/*cerebrospinal fluid
MH  - Prospective Studies
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Children
OT  - Epstein-Barr virus
OT  - Meningoencephalitis
OT  - Nerve growth factor
EDAT- 2014/01/11 06:00
MHDA- 2014/10/28 06:00
CRDT- 2014/01/11 06:00
PHST- 2013/09/13 00:00 [received]
PHST- 2013/11/12 00:00 [revised]
PHST- 2013/11/16 00:00 [accepted]
PHST- 2014/01/11 06:00 [entrez]
PHST- 2014/01/11 06:00 [pubmed]
PHST- 2014/10/28 06:00 [medline]
AID - S1201-9712(13)00359-7 [pii]
AID - 10.1016/j.ijid.2013.11.006 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2014 Mar;20:52-7. doi: 10.1016/j.ijid.2013.11.006. Epub 2014 
      Jan 7.