PMID- 24407232
OWN - NLM
STAT- MEDLINE
DCOM- 20140617
LR  - 20220410
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Linking)
VI  - 53
IP  - 5
DP  - 2014 May
TI  - The effects of gout on left atrial volume remodelling: a prospective 
      echocardiographic study.
PG  - 867-74
LID - 10.1093/rheumatology/ket444 [doi]
AB  - OBJECTIVE: The aim of the present study was to investigate the effect of gout on 
      left ventricular (LV) diastolic function and left atrial volume (LAV). METHODS: A 
      total of 173 patients were divided into four groups: control (n = 35), 
      asymptomatic hyperuricaemia (n = 30), gouty arthritis without tophi (n = 58) and 
      gouty tophi (n = 50). Patients underwent a comprehensive Doppler echocardiography 
      examination to evaluate LV volume, systolic and diastolic function and LAV and 
      function. RESULTS: Serum uric acid levels were not significantly different in the 
      asymptomatic hyperuricaemia, gouty arthritis without tophi and gouty tophi 
      groups. However, the ratio of the transmitral and myocardial peak early diastolic 
      velocities (E/e') and LAV index (LAVi) progressively increased from the control 
      group to the gouty tophi group. The tophi group had significantly higher E/e' 
      [10.5 (s.d. 3.2) vs 8.6 (s.d. 2.1), P = 0.008] and larger maximal, 
      pre-contraction and minimal LAVi [29.6 ml/m(2) (s.d. 9.9) vs 20.1 ml/m(2) (s.d. 
      4.8); 19.1 ml/m(2) (s.d. 8.5) vs 11.5 ml/m(2) (s.d. 3.4); 9.6 ml/m(2) (s.d. 4.2) 
      vs 6.1 ml/m(2) (s.d. 2.2); all P < 0.001] than the control group. By binary 
      logistic analysis, maximal LAVi was an independent predictor for the development 
      of tophi in gout patients, with an odds ratio of 1.068 (95% CI 1.02, 1.118; P = 
      0.005). CONCLUSION: The severity of gout had a significant effect on LV diastolic 
      dysfunction and LA enlargement in gout patients. Additionally, a high maximal 
      LAVi predicted the development of tophi and may be a predictor of adverse 
      cardiovascular events related to LA and LV remodelling in this clinical setting.
FAU - Pan, Kuo-Li
AU  - Pan KL
AD  - Division of Cardiology, Chang Gung Memorial Hospital, No. 6, West Chia-Pu Road, 
      Putz, Chiayi Hsien, Taiwan 613, Republic of China. pankuoli64@gmail.com.
FAU - Lin, Jing-Chi
AU  - Lin JC
FAU - Lin, Chun-Liang
AU  - Lin CL
FAU - Chen, Mien-Cheng
AU  - Chen MC
FAU - Chang, Pey-Jium
AU  - Chang PJ
FAU - Hsiao, Ju-Feng
AU  - Hsiao JF
FAU - Chang, Shih-Tai
AU  - Chang ST
FAU - Chung, Chang-Min
AU  - Chung CM
LA  - eng
PT  - Journal Article
DEP - 20140109
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Gouty/*complications
MH  - *Atrial Remodeling
MH  - *Cardiac Volume
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Echocardiography, Doppler
MH  - Female
MH  - Gout/*complications
MH  - Heart Atria/*diagnostic imaging/pathology/physiopathology
MH  - Heart Ventricles/diagnostic imaging/pathology/physiopathology
MH  - Humans
MH  - Hyperuricemia/*complications
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Uric Acid/blood
MH  - Ventricular Dysfunction, Left/physiopathology
MH  - Ventricular Remodeling
OTO - NOTNLM
OT  - diastolic dysfunction
OT  - gout
OT  - left atrial volume
OT  - uric acid
EDAT- 2014/01/11 06:00
MHDA- 2014/06/18 06:00
CRDT- 2014/01/11 06:00
PHST- 2014/01/11 06:00 [entrez]
PHST- 2014/01/11 06:00 [pubmed]
PHST- 2014/06/18 06:00 [medline]
AID - ket444 [pii]
AID - 10.1093/rheumatology/ket444 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2014 May;53(5):867-74. doi: 10.1093/rheumatology/ket444. 
      Epub 2014 Jan 9.