PMID- 24407463
OWN - NLM
STAT- MEDLINE
DCOM- 20150305
LR  - 20211021
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 29
IP  - 2
DP  - 2014 Jun
TI  - Methamphetamine reversed maternal separation-induced decrease in nerve growth 
      factor in the ventral hippocampus.
PG  - 433-9
LID - 10.1007/s11011-014-9481-z [doi]
AB  - Stress has been suggested to predispose individuals to drug abuse. The early life 
      stress of maternal separation (MS) is known to alter the response to drugs of 
      abuse later in life. Exposure to either stress or methamphetamine has been shown 
      to alter neurotrophic factors in the brain. Changes in neurotrophin levels may 
      contribute to the underlying molecular mechanisms responsible for drug use- and 
      stress-induced behaviours. The purpose of the present study was to investigate 
      the individual effects of MS and methamphetamine administration during 
      adolescence and the combined effects of both stressors on brain-derived 
      neurotrophic factor (BDNF) and nerve growth factor (NGF) levels in the dorsal and 
      ventral hippocampus (HC) in adulthood. Methamphetamine administration (1 mg/kg, 
      daily from postnatal day (PND) 33 to 36 and from PND 39 to 42), MS and the 
      combination of the two stressors resulted in decreased BDNF levels in both the 
      dorsal and ventral HC. MS decreased NGF levels in the ventral HC which was 
      restored by methamphetamine administration in adolescence. In the dorsal HC, NGF 
      remained unaltered by either stressor alone or in combination. We propose that 
      the restoration of NGF levels in the ventral HC may reflect a possible 
      compensatory mechanism in response to methamphetamine exposure in adolescence 
      following the early life stress of MS.
FAU - Dimatelis, J J
AU  - Dimatelis JJ
AD  - Department of Human Biology, Faculty of Health Sciences, University of Cape Town, 
      Anzio Road, Observatory, Cape Town, South Africa, 7925, 
      jacqueline.dimatelis@uct.ac.za.
FAU - Russell, V A
AU  - Russell VA
FAU - Stein, D J
AU  - Stein DJ
FAU - Daniels, W M
AU  - Daniels WM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140111
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
RN  - 0 (Biomarkers)
RN  - 44RAL3456C (Methamphetamine)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Female
MH  - Hippocampus/drug effects/*metabolism
MH  - Male
MH  - *Maternal Deprivation
MH  - Methamphetamine/*pharmacology
MH  - Nerve Growth Factor/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2014/01/11 06:00
MHDA- 2015/03/07 06:00
CRDT- 2014/01/11 06:00
PHST- 2013/10/13 00:00 [received]
PHST- 2014/01/03 00:00 [accepted]
PHST- 2014/01/11 06:00 [entrez]
PHST- 2014/01/11 06:00 [pubmed]
PHST- 2015/03/07 06:00 [medline]
AID - 10.1007/s11011-014-9481-z [doi]
PST - ppublish
SO  - Metab Brain Dis. 2014 Jun;29(2):433-9. doi: 10.1007/s11011-014-9481-z. Epub 2014 
      Jan 11.