PMID- 24407502
OWN - NLM
STAT- MEDLINE
DCOM- 20140926
LR  - 20190930
IS  - 1560-2281 (Electronic)
IS  - 1083-3668 (Linking)
VI  - 19
IP  - 1
DP  - 2014 Jan
TI  - Reduction of shading-derived artifacts in skin chromophore imaging without 
      measurements or assumptions about the shape of the subject.
PG  - 16009
LID - 10.1117/1.JBO.19.1.016009 [doi]
AB  - To quantitatively evaluate skin chromophores over a wide region of curved skin 
      surface, we propose an approach that suppresses the effect of the shading-derived 
      error in the reflectance on the estimation of chromophore concentrations, without 
      sacrificing the accuracy of that estimation. In our method, we use multiple 
      regression analysis, assuming the absorbance spectrum as the response variable 
      and the extinction coefficients of melanin, oxygenated hemoglobin, and 
      deoxygenated hemoglobin as the predictor variables. The concentrations of melanin 
      and total hemoglobin are determined from the multiple regression coefficients 
      using compensation formulae (CF) based on the diffuse reflectance spectra derived 
      from a Monte Carlo simulation. To suppress the shading-derived error, we 
      investigated three different combinations of multiple regression coefficients for 
      the CF. In vivo measurements with the forearm skin demonstrated that the proposed 
      approach can reduce the estimation errors that are due to shading-derived errors 
      in the reflectance. With the best combination of multiple regression 
      coefficients, we estimated that the ratio of the error to the chromophore 
      concentrations is about 10%. The proposed method does not require any 
      measurements or assumptions about the shape of the subjects; this is an advantage 
      over other studies related to the reduction of shading-derived errors.
FAU - Yoshida, Kenichiro
AU  - Yoshida K
AD  - Kao Corporation, Beauty Research Center, 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, 
      Japan.
FAU - Nishidate, Izumi
AU  - Nishidate I
AD  - Tokyo University of Agriculture & Technology, Graduate School of Bio-applications 
      & Systems Engineering, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
FAU - Ojima, Nobutoshi
AU  - Ojima N
AD  - Kao Corporation, Beauty Research Center, 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, 
      Japan.
FAU - Iwata, Kayoko
AU  - Iwata K
AD  - Kao Corporation, Beauty Research Center, 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, 
      Japan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biomed Opt
JT  - Journal of biomedical optics
JID - 9605853
RN  - 0 (Hemoglobins)
RN  - 0 (Melanins)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Artifacts
MH  - Diagnostic Imaging/*methods
MH  - Equipment Design
MH  - Hemoglobins/chemistry
MH  - Humans
MH  - Light
MH  - Melanins/chemistry
MH  - Middle Aged
MH  - Models, Biological
MH  - Monte Carlo Method
MH  - Oxygen/chemistry
MH  - Regression Analysis
MH  - Reproducibility of Results
MH  - Skin/*pathology
MH  - Young Adult
EDAT- 2014/01/11 06:00
MHDA- 2014/09/27 06:00
CRDT- 2014/01/11 06:00
PHST- 2013/08/21 00:00 [received]
PHST- 2013/12/09 00:00 [accepted]
PHST- 2014/01/11 06:00 [entrez]
PHST- 2014/01/11 06:00 [pubmed]
PHST- 2014/09/27 06:00 [medline]
AID - 1813449 [pii]
AID - 10.1117/1.JBO.19.1.016009 [doi]
PST - ppublish
SO  - J Biomed Opt. 2014 Jan;19(1):16009. doi: 10.1117/1.JBO.19.1.016009.