PMID- 2440817
OWN - NLM
STAT- MEDLINE
DCOM- 19870915
LR  - 20190816
IS  - 0020-5915 (Print)
IS  - 0020-5915 (Linking)
VI  - 83
IP  - 4
DP  - 1987
TI  - Studies on immunity in hybridoma-bearing mice. A. Immune response to antigens. 
      II. inhibition of production of anti-dinitrophenyl antibodies in mice which have 
      rejected the B 53 anti-dinitrophenyl-producing IgE hybridoma.
PG  - 414-22
AB  - When BALB/c mice, which had rejected the anti-dinitrophenyl (DNP) IgE-producing 
      hybridoma B 53, were immunized with DNP proteins, they produced much less 
      anti-DNP antibodies than control (normal) mice. The anti-DNP plaque-forming cell 
      (PFC) number was much less when spleen cells from mice immunized with DNP 
      proteins were treated with sera of mice which had rejected the hybridoma B 53 
      than the PFC number from the same spleen cells not treated by the sera. The sera 
      of mice which had rejected the hybridoma B 53 contained an inhibitor which was 
      adsorbed and eluted from an anti-mouse immunoglobulin column and also a mouse 
      anti-DNP IgG2a column. The inhibition of PFC was hapten-reversible. In Western 
      blotting the eluates from the anti-DNP IgG2a column reacted as well with the 
      blotted anti-DNP IgE B 53 as an anti-idiotypic antibody to anti-DNP IgE B 53. 
      These criteria establish that the inhibitor in the sera of the mice which had 
      rejected the B 53 tumor was an anti-idiotypic antibody of the type which mimics 
      the epitope (DNP) of the immunizing antigen.
FAU - Yin, J Z
AU  - Yin JZ
FAU - Furusawa, S
AU  - Furusawa S
FAU - Hirano, T
AU  - Hirano T
FAU - Ovary, Z
AU  - Ovary Z
LA  - eng
GR  - AI-03075/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Int Arch Allergy Appl Immunol
JT  - International archives of allergy and applied immunology
JID - 0404561
RN  - 0 (Antibodies)
RN  - 0 (Antigens)
RN  - 0 (Autoantibodies)
RN  - 0 (Dinitrobenzenes)
RN  - 0 (Epitopes)
RN  - 0 (Haptens)
RN  - 0 (Immunoglobulin Idiotypes)
RN  - 0 (Nitrobenzenes)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9004-70-0 (Collodion)
SB  - IM
MH  - Animals
MH  - Antibodies/*immunology/isolation & purification
MH  - *Antibody Formation
MH  - Antigens/*administration & dosage/immunology
MH  - Autoantibodies/biosynthesis/immunology
MH  - Collodion
MH  - Dinitrobenzenes/administration & dosage/*immunology
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Epitopes/immunology
MH  - Female
MH  - *Graft Rejection
MH  - Haptens/immunology
MH  - Hemolytic Plaque Technique
MH  - Hybridomas/classification/immunology/metabolism/*transplantation
MH  - Immunoglobulin E/*metabolism
MH  - Immunoglobulin Idiotypes/immunology/isolation & purification
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred Strains
MH  - Nitrobenzenes/*immunology
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.1159/000234378 [doi]
PST - ppublish
SO  - Int Arch Allergy Appl Immunol. 1987;83(4):414-22. doi: 10.1159/000234378.