PMID- 24409132
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140110
LR  - 20211021
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 7
DP  - 2013
TI  - Sex differences in stress-induced social withdrawal: role of brain derived 
      neurotrophic factor in the bed nucleus of the stria terminalis.
PG  - 223
LID - 10.3389/fnbeh.2013.00223 [doi]
LID - 223
AB  - Depression and anxiety disorders are more common in women than men, and little is 
      known about the neurobiological mechanisms that contribute to this disparity. 
      Recent data suggest that stress-induced changes in neurotrophins have opposing 
      effects on behavior by acting in different brain networks. Social defeat has been 
      an important approach for understanding neurotrophin action, but low female 
      aggression levels in rats and mice have limited the application of these methods 
      primarily to males. We examined the effects of social defeat in monogamous 
      California mice (Peromyscus californicus), a species in which both males and 
      females defend territories. We demonstrate that defeat stress increases mature 
      brain-derived neurotrophic factor (BDNF) protein but not mRNA in the bed nucleus 
      of the stria terminalis (BNST) in females but not males. Changes in BDNF protein 
      were limited to anterior subregions of the BNST, and there were no changes in the 
      adjacent nucleus accumbens (NAc). The effects of defeat on social withdrawal 
      behavior and BDNF were reversed by chronic, low doses of the antidepressant 
      sertraline. However, higher doses of sertraline restored social withdrawal and 
      elevated BDNF levels. Acute treatment with a low dose of sertraline failed to 
      reverse the effects of defeat. Infusions of the selective tyrosine-related kinase 
      B receptor (TrkB) antagonist ANA-12 into the anterior BNST specifically increased 
      social interaction in stressed females but had no effect on behavior in females 
      naive to defeat. These results suggest that stress-induced increases in BDNF in 
      the anterior BNST contribute to the exaggerated social withdrawal phenotype 
      observed in females.
FAU - Greenberg, Gian D
AU  - Greenberg GD
AD  - Neuroscience Graduate Group, University of California Davis, CA, USA ; Department 
      of Psychology, University of California Davis, CA, USA ; Center for Neuroscience, 
      University of California Davis, CA, USA.
FAU - Laman-Maharg, Abigail
AU  - Laman-Maharg A
AD  - Neuroscience Graduate Group, University of California Davis, CA, USA ; Center for 
      Neuroscience, University of California Davis, CA, USA.
FAU - Campi, Katharine L
AU  - Campi KL
AD  - Department of Psychology, University of California Davis, CA, USA.
FAU - Voigt, Heather
AU  - Voigt H
AD  - Department of Psychology, University of California Davis, CA, USA.
FAU - Orr, Veronica N
AU  - Orr VN
AD  - Department of Psychology, University of California Davis, CA, USA.
FAU - Schaal, Leslie
AU  - Schaal L
AD  - Department of Psychology, University of California Davis, CA, USA.
FAU - Trainor, Brian C
AU  - Trainor BC
AD  - Neuroscience Graduate Group, University of California Davis, CA, USA ; Department 
      of Psychology, University of California Davis, CA, USA ; Center for Neuroscience, 
      University of California Davis, CA, USA.
LA  - eng
GR  - R01 MH097714/MH/NIMH NIH HHS/United States
GR  - R21 MH090392/MH/NIMH NIH HHS/United States
GR  - T32 MH082174/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20140109
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC3885825
OTO - NOTNLM
OT  - BDNF
OT  - BNST
OT  - SSRI
OT  - dose
OT  - sex
OT  - social defeat
EDAT- 2014/01/11 06:00
MHDA- 2014/01/11 06:01
PMCR- 2013/01/01
CRDT- 2014/01/11 06:00
PHST- 2013/10/29 00:00 [received]
PHST- 2013/12/22 00:00 [accepted]
PHST- 2014/01/11 06:00 [entrez]
PHST- 2014/01/11 06:00 [pubmed]
PHST- 2014/01/11 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2013.00223 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2014 Jan 9;7:223. doi: 10.3389/fnbeh.2013.00223. 
      eCollection 2013.