PMID- 24409183
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20220311
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 4
DP  - 2013 Dec 27
TI  - Dendritic cells: a spot on sialic Acid.
PG  - 491
LID - 10.3389/fimmu.2013.00491 [doi]
LID - 491
AB  - Glycans decorating cell surface and secreted proteins and lipids occupy the 
      juncture where critical host-host and host-pathogen interactions occur. The role 
      of glycan epitopes in cell-cell and cell-pathogen adhesive events is already 
      well-established, and cell surface glycan structures change rapidly in response 
      to stimulus and inflammatory cues. Despite the wide acceptance that glycans are 
      centrally implicated in immunity, exactly how glycans and their changes 
      contribute to the overall immune response remains poorly defined. Sialic acids 
      are unique sugars that usually occupy the terminal position of the glycan chains 
      and may be modified by external factors, such as pathogens, or upon specific 
      physiological cellular events. At cell surface, sialic acid-modified structures 
      form the key fundamental determinants for a number of receptors with known 
      involvement in cellular adhesiveness and cell trafficking, such as the Selectins 
      and the Siglec families of carbohydrate recognizing receptors. Dendritic cells 
      (DCs) preside over the transition from innate to the adaptive immune repertoires, 
      and no other cell has such relevant role in antigen screening, uptake, and its 
      presentation to lymphocytes, ultimately triggering the adaptive immune response. 
      Interestingly, sialic acid-modified structures are involved in all DC functions, 
      such as antigen uptake, DC migration, and capacity to prime T cell responses. 
      Sialic acid content changes along DC differentiation and activation and, while, 
      not yet fully understood, these changes have important implications in DC 
      functions. This review focuses on the developmental regulation of DC surface 
      sialic acids and how manipulation of DC surface sialic acids can affect 
      immune-critical DC functions by altering antigen endocytosis, pathogen and tumor 
      cell recognition, cell recruitment, and capacity for T cell priming. The existing 
      evidence points to a potential of DC surface sialylation as a therapeutic target 
      to improve and diversify DC-based therapies.
FAU - Crespo, Helio J
AU  - Crespo HJ
AD  - CEDOC - UC Imunologia, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa 
      , Lisbon , Portugal ; Department of Molecular and Cellular Biology, Roswell Park 
      Cancer Institute , Buffalo, NY , USA.
FAU - Lau, Joseph T Y
AU  - Lau JT
AD  - Department of Molecular and Cellular Biology, Roswell Park Cancer Institute , 
      Buffalo, NY , USA.
FAU - Videira, Paula A
AU  - Videira PA
AD  - CEDOC - UC Imunologia, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa 
      , Lisbon , Portugal.
LA  - eng
GR  - P01 HL107146/HL/NHLBI NIH HHS/United States
GR  - R01 AI056082/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20131227
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3873530
OTO - NOTNLM
OT  - dendritic cell
OT  - host-pathogen interaction
OT  - lectins
OT  - sialic acid
OT  - sialylation
EDAT- 2014/01/11 06:00
MHDA- 2014/01/11 06:01
PMCR- 2013/01/01
CRDT- 2014/01/11 06:00
PHST- 2013/09/30 00:00 [received]
PHST- 2013/12/15 00:00 [accepted]
PHST- 2014/01/11 06:00 [entrez]
PHST- 2014/01/11 06:00 [pubmed]
PHST- 2014/01/11 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2013.00491 [doi]
PST - epublish
SO  - Front Immunol. 2013 Dec 27;4:491. doi: 10.3389/fimmu.2013.00491.