PMID- 24409426
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140110
LR  - 20211021
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 9
IP  - 6
DP  - 2013
TI  - Age-dependent effect of treadmill exercise on hemorrhage-induced neuronal cell 
      death in rats.
PG  - 506-10
LID - 10.12965/jer.130070 [doi]
AB  - Intracerebral hemorrhage (ICH) is a major cause of death and disability in the 
      elderly. In the present study, we examined the age-dependence of the effect of 
      treadmill exercise on the intrastriatal hemorrhage-induced neuronal cell death in 
      rats. Young (8 weeks old) and old (64 weeks old) Sprague-Dawley male rats were 
      used in the present study. Intrastriatal hemorrhage was induced by injection of 
      0.2 U collagenase (1 muL volume) into the striatum using a stereotaxic instrument. 
      The rats in the exercise groups were forced to run on a treadmill for 30 min 
      daily for 7 days. Lesion size was determined by Nissl staining. Apoptosis was 
      assessed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end 
      labeling (TUNEL) assay. In the present results, induction of hemorrhage increased 
      lesion size and enhanced apoptosis. Treadmill exercise decreased the lesion size 
      with suppressing apoptosis. However, the size of lesion induced by hemorrhage and 
      the number of apoptotic cells were not different between young and old rats. 
      Treadmill exercise significantly reduced the ICH-induced lesion size and the 
      number of apoptotic cells irrespective of age. The data suggest that treadmill 
      exercise may provide therapeutic value against ICH by suppressing neuronal 
      apoptosis regardless of age.
FAU - Yoon, Jin-Hwan
AU  - Yoon JH
AD  - Department of Sports Science, College of Life Science and Nano Technology, Hannam 
      University, Daejeon, Korea.
FAU - Lee, Hee-Hyuk
AU  - Lee HH
AD  - Department of Sports Science, College of Life Science and Nano Technology, Hannam 
      University, Daejeon, Korea.
FAU - Yi, Eun-Surk
AU  - Yi ES
AD  - Department of Exercise Rehabilitation & Welfare, College of Health Science, 
      Gachon University, Incheon, Korea.
FAU - Baek, Soon Gi
AU  - Baek SG
AD  - Department of Sports Health Medicine, College of Health Science, Jungwon 
      University, Chungcheongbuk-do, Korea.
LA  - eng
PT  - Journal Article
DEP - 20131231
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC3884869
OTO - NOTNLM
OT  - Age-dependence
OT  - Apoptosis
OT  - Intrastriatal hemorrhage
OT  - Lesion size
OT  - Striatum
OT  - Treadmill exercise
EDAT- 2014/01/11 06:00
MHDA- 2014/01/11 06:01
PMCR- 2013/12/31
CRDT- 2014/01/11 06:00
PHST- 2013/10/23 00:00 [received]
PHST- 2013/11/13 00:00 [revised]
PHST- 2013/12/09 00:00 [accepted]
PHST- 2014/01/11 06:00 [entrez]
PHST- 2014/01/11 06:00 [pubmed]
PHST- 2014/01/11 06:01 [medline]
PHST- 2013/12/31 00:00 [pmc-release]
AID - jer-9-6-506-4 [pii]
AID - 10.12965/jer.130070 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2013 Dec 31;9(6):506-10. doi: 10.12965/jer.130070. eCollection 
      2013.