PMID- 24410783
OWN - NLM
STAT- MEDLINE
DCOM- 20140813
LR  - 20220129
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 68
IP  - 12
DP  - 2013 Dec
TI  - Twenty four-hour helpline access to expert management advice for 
      food-allergy-triggered anaphylaxis in infants, children and young people: a 
      pragmatic, randomized controlled trial.
PG  - 1598-604
LID - 10.1111/all.12310 [doi]
AB  - BACKGROUND: Anaphylaxis is a life-threatening emergency. If promptly 
      administered, adrenaline is potentially life-saving. Many 
      food-allergic-children/carers are unsure when to use their adrenaline 
      autoinjectors, contributing to a low quality of life and worse outcomes in the 
      setting of an acute allergic reaction. OBJECTIVES: The aim of this study was to 
      assess the effectiveness of 24-hour telephone access to specialist clinical 
      advice on disease-specific quality of life. METHODS: A pragmatic two-arm, 
      parallel-group randomized control trial was conducted. Children/carers 
      (<16 years) with food allergy, trained in adrenaline auto-injector use, were 
      recruited from a hospital-based paediatric allergy clinic. Baseline 
      disease-specific quality of life was ascertained using the validated 
      Food-Allergy-Related Quality-of-Life Questionnaire (FAQLQ), either Parent Form, 
      Child Form or Teenager Form depending on child's age. Participants were then 
      centrally randomized for a 6-month period to 24-hour telephone specialist support 
      line or to usual care. The primary outcome measure was a change in FAQL scores, 
      at one and 6 months postrandomization, compared with baseline. The minimum 
      clinically important difference (MCID) in score is 0.5. RESULTS: Fifty two 
      children/carers were recruited. FAQL scores remained static in the control group 
      across the three time points. Scores gradually improved in the intervention 
      group, with a significant difference seen at 6 months (T1-T3 Mean 
      difference = -1.5, (CI 0.87-2.25) P < 0.005] Follow-up questionnaires, 6 months 
      after the intervention was removed, T4, showed sustained significant difference 
      between the groups (control M = 3.0; intervention M = 1.1[t = -4.113, P < 0.05]). 
      CONCLUSION: The 24-hour helpline improved food-allergy-specific quality of life 
      in children. Six-month intervention support resulted in sustained benefits for at 
      least a further 6 months.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Kelleher, M M
AU  - Kelleher MM
AD  - Department of Paediatrics & Child Health, University College Cork, Cork, Ireland.
FAU - Dunngalvin, A
AU  - Dunngalvin A
FAU - Sheikh, A
AU  - Sheikh A
FAU - Cullinane, C
AU  - Cullinane C
FAU - Fitzsimons, J
AU  - Fitzsimons J
FAU - Hourihane, J O'B
AU  - Hourihane JO
LA  - eng
GR  - CZG/2/454/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
SB  - IM
MH  - Adolescent
MH  - Anaphylaxis/*etiology/*prevention & control
MH  - Child
MH  - Child, Preschool
MH  - *Consultants
MH  - Female
MH  - Food Hypersensitivity/*complications
MH  - *Hotlines
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Patient Outcome Assessment
MH  - *Quality of Life
MH  - Young Adult
OTO - NOTNLM
OT  - adrenaline
OT  - anaphylaxis
OT  - food allergy
OT  - paediatrics
OT  - quality of life
EDAT- 2014/01/15 06:00
MHDA- 2014/08/15 06:00
CRDT- 2014/01/14 06:00
PHST- 2013/09/30 00:00 [accepted]
PHST- 2014/01/14 06:00 [entrez]
PHST- 2014/01/15 06:00 [pubmed]
PHST- 2014/08/15 06:00 [medline]
AID - 10.1111/all.12310 [doi]
PST - ppublish
SO  - Allergy. 2013 Dec;68(12):1598-604. doi: 10.1111/all.12310.