PMID- 24411588
OWN - NLM
STAT- MEDLINE
DCOM- 20141126
LR  - 20140411
IS  - 1879-0461 (Electronic)
IS  - 1040-8428 (Linking)
VI  - 90
IP  - 2
DP  - 2014 May
TI  - Human umbilical cord blood-derived stromal cells: A new source of stromal cells 
      in hematopoietic stem cell transplantation.
PG  - 93-8
LID - S1040-8428(13)00257-6 [pii]
LID - 10.1016/j.critrevonc.2013.12.002 [doi]
AB  - The hematopoietic inductive microenvironment (HIM), which is composed of stromal 
      cells, extracellular matrix and cytokines, plays a vital role in hematopoietic 
      stem cell transplantation (HSCT). Bone marrow stromal cells (BMSCs), as the main 
      component of HIM, have been well studied. However, the highly invasive procedure 
      of bone marrow (BM) collection limits the clinical application of BMSCs. Human 
      umbilical cord blood-derived stromal cells (hUCBDSCs) isolated and cultured in 
      our laboratory have attracted much attention for their ease collection and low 
      probability of pathophoresis. Previous research demonstrated that hUCBDSCs have 
      numerous functions that are identical to those of BMSCs, for example, hUCBDSCs 
      can support the growth of hematopoietic stem and progenitor cells, especially 
      during the expansion of megakaryocyte colony-forming units (CFU-Mk), promote 
      engraftment after hematopoietic stem cell transplantation (HSCT), exert 
      immunosuppressive effects on xenogenic T cells in vitro and suppress acute 
      graft-versus-host disease (aGVHD) in vivo. Although hUCBDSCs, as new stromal 
      cells, have not been used in clinical practice, they have great practical 
      significance because of their superiority in hematopoiesis and the regulation of 
      immunity.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Liu, Shan-Shan
AU  - Liu SS
AD  - Department of Hematology, Xinqiao Hospital, The Third Military Medical 
      University, Chongqing 400037, People's Republic of China.
FAU - Zhang, Cheng
AU  - Zhang C
AD  - Department of Hematology, Xinqiao Hospital, The Third Military Medical 
      University, Chongqing 400037, People's Republic of China.
FAU - Zhang, Xi
AU  - Zhang X
AD  - Department of Hematology, Xinqiao Hospital, The Third Military Medical 
      University, Chongqing 400037, People's Republic of China.
FAU - Chen, Xing-Hua
AU  - Chen XH
AD  - Department of Hematology, Xinqiao Hospital, The Third Military Medical 
      University, Chongqing 400037, People's Republic of China. Electronic address: 
      xhchen888@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131211
PL  - Netherlands
TA  - Crit Rev Oncol Hematol
JT  - Critical reviews in oncology/hematology
JID - 8916049
SB  - IM
MH  - Fetal Blood/*cytology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Stromal Cells/*cytology/transplantation
OTO - NOTNLM
OT  - Graft-versus-host disease
OT  - Hematopoietic stem cell transplantation
OT  - Human umbilical cord blood-derived mesenchymal cells
OT  - Human umbilical cord blood-derived stromal cells
EDAT- 2014/01/15 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/14 06:00
PHST- 2013/08/14 00:00 [received]
PHST- 2013/10/21 00:00 [revised]
PHST- 2013/12/03 00:00 [accepted]
PHST- 2014/01/14 06:00 [entrez]
PHST- 2014/01/15 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S1040-8428(13)00257-6 [pii]
AID - 10.1016/j.critrevonc.2013.12.002 [doi]
PST - ppublish
SO  - Crit Rev Oncol Hematol. 2014 May;90(2):93-8. doi: 
      10.1016/j.critrevonc.2013.12.002. Epub 2013 Dec 11.