PMID- 24412470
OWN - NLM
STAT- MEDLINE
DCOM- 20141021
LR  - 20161125
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 19
IP  - 1
DP  - 2014 Mar
TI  - Imbalanced expression of human Tim-1 and Tim-3 in peripheral blood mononuclear 
      cells from immune thrombocytopenia patients.
PG  - 1-4
LID - S1567-5769(13)00516-X [pii]
LID - 10.1016/j.intimp.2013.12.025 [doi]
AB  - BACKGROUND: The T-cell immunoglobulin and mucin domain-(Tim)-1 molecule and Tim-3 
      are mainly expressed on activated T helper (Th) 2 and Th1 cells, respectively, 
      and have been implicated in the pathogenesis of some autoimmune diseases. Immune 
      thrombocytopenia (ITP) is a common autoimmune disorder, and the complex 
      dysregulation of cellular immunity has been observed; however, the relationship 
      between Tims and excessive immune responses in ITP remains unclear. METHODS: 
      Using real-time quantitative polymerase chain reaction (RT-PCR), the mRNA 
      expression levels of Tim-1, Tim-3, T-box transcription factor (T-bet) and GATA 
      binding protein 3 (GATA-3) were measured in the peripheral blood mononuclear 
      cells (PBMCs) of 45 newly diagnosed patients with active ITP, 34 ITP patients in 
      remission and 31 healthy volunteers. RESULTS: Tim-3 mRNA expression in PBMCs in 
      newly diagnosed patients was significantly decreased. At the same time, Tim-1 
      mRNA was not significantly declined, which resulted in a decreased ratio of Tim-3 
      to Tim-1 in ITP patients with active disease. During the remission stages, the 
      levels of these transcription factors were comparable with those observed in 
      healthy controls. CONCLUSIONS: The reduced levels of Tim-3/Tim-1 in PBMCs during 
      active stages of the disease suggest a possible role in the pathogenesis and 
      course of ITP. Regulating the balance of Tim-1 and Tim-3 in ITP patients could 
      also be a therapeutic approach against ITP.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Zhang, Xiao-mei
AU  - Zhang XM
AD  - Department of Hematology, Shandong provincial Hospital affiliated to Shandong 
      University, Jinan, 250021,China.
FAU - Shan, Ning-ning
AU  - Shan NN
AD  - Department of Hematology, Shandong provincial Hospital affiliated to Shandong 
      University, Jinan, 250021,China. Electronic address: snning@126.com.
FAU - Sun, Ming
AU  - Sun M
AD  - Department of Hematology, Linzi District People's Hospital, Zibo, 255100,China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Hematology, Shandong provincial Hospital affiliated to Shandong 
      University, Jinan, 250021,China.
FAU - Feng, Xiu-mei
AU  - Feng XM
AD  - Department of Hematology, Shandong provincial Hospital affiliated to Shandong 
      University, Jinan, 250021,China.
FAU - Liu, Xin
AU  - Liu X
AD  - Department of Hematology, Shandong provincial Hospital affiliated to Shandong 
      University, Jinan, 250021,China.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Hematology, Shandong provincial Hospital affiliated to Shandong 
      University, Jinan, 250021,China.
FAU - Yuan, Dai
AU  - Yuan D
AD  - Department of Hematology, Shandong provincial Hospital affiliated to Shandong 
      University, Jinan, 250021,China.
FAU - Ding, Mei
AU  - Ding M
AD  - Department of Hematology, Shandong provincial Hospital affiliated to Shandong 
      University, Jinan, 250021,China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140107
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (HAVCR1 protein, human)
RN  - 0 (HAVCR2 protein, human)
RN  - 0 (Hepatitis A Virus Cellular Receptor 1)
RN  - 0 (Hepatitis A Virus Cellular Receptor 2)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Virus)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (T-box transcription factor TBX21)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - GATA3 Transcription Factor/genetics
MH  - Hepatitis A Virus Cellular Receptor 1
MH  - Hepatitis A Virus Cellular Receptor 2
MH  - Humans
MH  - Leukocytes, Mononuclear/*metabolism
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Membrane Proteins/*genetics
MH  - Middle Aged
MH  - RNA, Messenger/metabolism
MH  - Receptors, Virus/*genetics
MH  - T-Box Domain Proteins/genetics
MH  - Thrombocytopenia/*blood/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Immune thrombocytopenia
OT  - RT-PCR
OT  - T-cell immunoglobulin and mucin domain-3
OT  - Tim-1
EDAT- 2014/01/15 06:00
MHDA- 2014/10/22 06:00
CRDT- 2014/01/14 06:00
PHST- 2013/11/03 00:00 [received]
PHST- 2013/12/20 00:00 [revised]
PHST- 2013/12/24 00:00 [accepted]
PHST- 2014/01/14 06:00 [entrez]
PHST- 2014/01/15 06:00 [pubmed]
PHST- 2014/10/22 06:00 [medline]
AID - S1567-5769(13)00516-X [pii]
AID - 10.1016/j.intimp.2013.12.025 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2014 Mar;19(1):1-4. doi: 10.1016/j.intimp.2013.12.025. Epub 
      2014 Jan 7.