PMID- 24412578
OWN - NLM
STAT- MEDLINE
DCOM- 20140816
LR  - 20140203
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 32
IP  - 9
DP  - 2014 Feb 19
TI  - Dynamic profiles of neutralizing antibody responses elicited in rhesus monkeys 
      immunized with a combined tetravalent DTaP-Sabin IPV candidate vaccine.
PG  - 1100-6
LID - S0264-410X(13)01756-8 [pii]
LID - 10.1016/j.vaccine.2013.12.025 [doi]
AB  - The World Health Organization has recommended that a Sabin inactivated polio 
      vaccine (IPV) should gradually and synchronously replace oral polio vaccines for 
      routine immunizations because its benefits in eliminating vaccine-associated 
      paralytic poliomyelitis have been reported in different phases of clinical 
      trials. It is also considered important to explore new tetravalent diphtheria, 
      tetanus, and acellular pertussis-Sabin IPV (DTaP-sIPV) candidate vaccines for 
      possible use in developing countries. In this study, the immunogenicity of a 
      combined tetravalent DTaP-sIPV candidate vaccine was investigated in primates by 
      evaluating the neutralizing antibody responses it induced. The dynamic profiles 
      of the antibody responses to each of the separate antigenic components and 
      serotypes of Sabin IPV were determined and their corresponding geometric mean 
      titers were similar to those generated by the tetravalent diphtheria, tetanus, 
      and acellular pertussis-conventional IPV (DTaP-cIPV), the tetravalent diphtheria, 
      tetanus, and acellular pertussis (DTaP), and Sabin IPV vaccines in the control 
      groups. This implies that protective immunogenic effects are conferred by this 
      combined tetravalent formulation.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Sun, Mingbo
AU  - Sun M
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Yunnan Key Laboratory of Vaccine Research & Development on 
      Severe Infectious Disease, Kunming 650118, China. Electronic address: 
      smb@imbcams.com.cn.
FAU - Ma, Yan
AU  - Ma Y
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Yunnan Key Laboratory of Vaccine Research & Development on 
      Severe Infectious Disease, Kunming 650118, China.
FAU - Xu, Yinhua
AU  - Xu Y
AD  - National Institutes for Food and Drug Control, Beijing 100050, China.
FAU - Yang, Huijuan
AU  - Yang H
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Yunnan Key Laboratory of Vaccine Research & Development on 
      Severe Infectious Disease, Kunming 650118, China.
FAU - Shi, Li
AU  - Shi L
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Yunnan Key Laboratory of Vaccine Research & Development on 
      Severe Infectious Disease, Kunming 650118, China.
FAU - Che, Yanchun
AU  - Che Y
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Yunnan Key Laboratory of Vaccine Research & Development on 
      Severe Infectious Disease, Kunming 650118, China.
FAU - Liao, Guoyang
AU  - Liao G
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Yunnan Key Laboratory of Vaccine Research & Development on 
      Severe Infectious Disease, Kunming 650118, China.
FAU - Jiang, Shude
AU  - Jiang S
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Yunnan Key Laboratory of Vaccine Research & Development on 
      Severe Infectious Disease, Kunming 650118, China.
FAU - Zhang, Shumin
AU  - Zhang S
AD  - National Institutes for Food and Drug Control, Beijing 100050, China. Electronic 
      address: zhangsm@nifdc.org.cn.
FAU - Li, Qihan
AU  - Li Q
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Yunnan Key Laboratory of Vaccine Research & Development on 
      Severe Infectious Disease, Kunming 650118, China. Electronic address: 
      imbcams.lq@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140107
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Diphtheria-Tetanus-acellular Pertussis Vaccines)
RN  - 0 (Poliovirus Vaccine, Inactivated)
RN  - 0 (Poliovirus Vaccine, Oral)
RN  - 0 (Vaccines, Combined)
SB  - IM
MH  - Animals
MH  - Antibodies, Bacterial/blood
MH  - Antibodies, Neutralizing/*blood
MH  - Antibodies, Viral/blood
MH  - Diphtheria/prevention & control
MH  - Diphtheria-Tetanus-acellular Pertussis Vaccines/*immunology
MH  - Macaca mulatta/immunology
MH  - Poliomyelitis/prevention & control
MH  - Poliovirus Vaccine, Inactivated/*immunology
MH  - Poliovirus Vaccine, Oral/*immunology
MH  - Tetanus/prevention & control
MH  - Vaccines, Combined/immunology
MH  - Whooping Cough/prevention & control
OTO - NOTNLM
OT  - DTaP-Sabin IPV
OT  - Immunogenicity
OT  - Rhesus monkey
EDAT- 2014/01/15 06:00
MHDA- 2014/08/17 06:00
CRDT- 2014/01/14 06:00
PHST- 2013/10/05 00:00 [received]
PHST- 2013/12/03 00:00 [revised]
PHST- 2013/12/10 00:00 [accepted]
PHST- 2014/01/14 06:00 [entrez]
PHST- 2014/01/15 06:00 [pubmed]
PHST- 2014/08/17 06:00 [medline]
AID - S0264-410X(13)01756-8 [pii]
AID - 10.1016/j.vaccine.2013.12.025 [doi]
PST - ppublish
SO  - Vaccine. 2014 Feb 19;32(9):1100-6. doi: 10.1016/j.vaccine.2013.12.025. Epub 2014 
      Jan 7.