PMID- 24415644
OWN - NLM
STAT- MEDLINE
DCOM- 20140404
LR  - 20140207
IS  - 1470-7926 (Electronic)
IS  - 1351-0711 (Linking)
VI  - 71
IP  - 3
DP  - 2014 Mar
TI  - Cognitive function and plasma BDNF levels among manganese-exposed smelters.
PG  - 189-94
LID - 10.1136/oemed-2013-101896 [doi]
AB  - OBJECTIVES: To explore the potential dose-response relationship between manganese 
      (Mn) exposure and cognitive function and also plasma brain-derived neurotrophic 
      factor (BDNF) levels in occupational Mn exposure workers. METHODS: A total 819 
      workers were identified from our Mn-exposed workers, and 293 control workers were 
      recruited in the same region. All exposed workers were divided into three groups 
      based on Mn cumulative exposure index. The Montreal Cognitive Assessment (MoCA) 
      test was applied to estimate cognitive function for all subjects. Plasma BDNF 
      levels were determined by ELISA in 248 selected exposed workers and 100 controls. 
      RESULTS: Mn-exposed workers had significantly lower MoCA scores than those in the 
      control group (25.62 +/- 0.25): those in high-exposure group had the lowest scores 
      (21.33 +/- 0.32), compared with the intermediate-exposure group (23.22 +/- 0.30) and 
      low-exposure group (23.57 +/- 0.23). Mn exposure levels were inversely associated 
      with MoCA total scores, all p<0.05. A positive correlation was found between 
      plasma BDNF levels and MoCA total scores (r=0.278, p<0.01). Moreover, compared 
      with the control group (288.7 +/- 181.7 pg/mL), BDNF levels were lower in the 
      high-exposure group (127.5 +/- 99.8 pg/mL), and in the intermediate-exposure (178.2 
      +/- 138.1 pg/mL) and low-exposure groups (223.4 +/- 178.3 pg/mL). Additionally, 
      plasma BDNF levels decreased significantly as Mn exposure levels increased 
      (ptrend<0.01). CONCLUSIONS: Mn exposure may be associated with decreased plasma 
      BDNF levels and cognition impairment in this large cross-sectional study.
FAU - Zou, Yunfeng
AU  - Zou Y
AD  - Department of Toxicology, School of Public Health, Guangxi Medical University, 
      Nanning, Guangxi, People's Republic of China.
FAU - Qing, Li
AU  - Qing L
FAU - Zeng, Xiaoyun
AU  - Zeng X
FAU - Shen, Yuefei
AU  - Shen Y
FAU - Zhong, Yaoqiu
AU  - Zhong Y
FAU - Liu, Jing
AU  - Liu J
FAU - Li, Qin
AU  - Li Q
FAU - Chen, Kangcheng
AU  - Chen K
FAU - Lv, Yingnan
AU  - Lv Y
FAU - Huang, Damin
AU  - Huang D
FAU - Liang, Guiqiang
AU  - Liang G
FAU - Zhang, Wei
AU  - Zhang W
FAU - Chen, Lang
AU  - Chen L
FAU - Yang, Yiping
AU  - Yang Y
FAU - Yang, Xiaobo
AU  - Yang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140110
PL  - England
TA  - Occup Environ Med
JT  - Occupational and environmental medicine
JID - 9422759
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 42Z2K6ZL8P (Manganese)
SB  - IM
MH  - Adult
MH  - Air Pollutants, Occupational/*adverse effects/analysis
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Cognition/*drug effects
MH  - Cognition Disorders/blood/*chemically induced
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Industry
MH  - Inhalation Exposure/adverse effects
MH  - Male
MH  - Manganese/*adverse effects
MH  - Occupational Diseases/blood/*chemically induced/psychology
MH  - Occupational Exposure/*adverse effects/analysis
MH  - Occupations
EDAT- 2014/01/15 06:00
MHDA- 2014/04/05 06:00
CRDT- 2014/01/14 06:00
PHST- 2014/01/14 06:00 [entrez]
PHST- 2014/01/15 06:00 [pubmed]
PHST- 2014/04/05 06:00 [medline]
AID - oemed-2013-101896 [pii]
AID - 10.1136/oemed-2013-101896 [doi]
PST - ppublish
SO  - Occup Environ Med. 2014 Mar;71(3):189-94. doi: 10.1136/oemed-2013-101896. Epub 
      2014 Jan 10.