PMID- 24415683
OWN - NLM
STAT- MEDLINE
DCOM- 20141125
LR  - 20220408
IS  - 1615-9314 (Electronic)
IS  - 1615-9306 (Linking)
VI  - 37
IP  - 6
DP  - 2014 Mar
TI  - Metabolomics analysis reveals variation in Schisandra chinensis cetabolites from 
      different origins.
PG  - 731-7
LID - 10.1002/jssc.201301242 [doi]
AB  - Wu Wei Zi (Schisandra chinensis), an important herbal medicine, is mainly 
      distributed in the northeast of China. Its phytochemical compositions, which 
      depend on geographical origin, climatic conditions and cultural practices, may 
      vary largely among Wu Wei Zi from different areas. In this study, we applied a 
      comprehensive metabolite profiling approach using GC-TOF-MS, ultra-performance LC 
      (UPLC) quadrupole TOF (QTOF) MS and inductively coupled plasma MS to 
      systematically investigate the metabolite variations of S. chinensis from four 
      different areas including Heilongjiang, Liaoning, Jilin, and Shanxi of China. A 
      total of 65 primary metabolites, 35 secondary metabolites and 64 inorganic 
      elements were identified. Several primary metabolites, including shikimic acid 
      and tricarboxylic acid cycle intermediates, were abundant in those located in 
      Heilongjiang, Jilin, and Liaoning. Besides, bioactive lignans are also highly 
      abundant in those from northeastern China than those from northwestern China. 
      Inorganic elements varied significantly among the different locations. Our 
      results suggested that the metabolite profiling approach using GC-TOF-MS, 
      ultra-performance LC quadrupole TOF MS, and inductively coupled plasma MS is a 
      robust and reliable method that can be effectively used to explore subtle 
      variations among plants from different geographical locations.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Zhang, Yinan
AU  - Zhang Y
AD  - Center for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, 
      Department of Endocrinology and Metabolism, Shanghai Jiao Tong University 
      Affiliated Sixth People's Hospital, Shanghai, P.R. China.
FAU - Li, Fen
AU  - Li F
FAU - Huang, Fengjie
AU  - Huang F
FAU - Xie, Guoxiang
AU  - Xie G
FAU - Wei, Runmin
AU  - Wei R
FAU - Chen, Tianlu
AU  - Chen T
FAU - Liu, Jiajian
AU  - Liu J
FAU - Zhao, Aihua
AU  - Zhao A
FAU - Jia, Wei
AU  - Jia W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - J Sep Sci
JT  - Journal of separation science
JID - 101088554
SB  - IM
MH  - Chromatography, High Pressure Liquid
MH  - Mass Spectrometry
MH  - *Metabolomics
MH  - Schisandra/*chemistry/*metabolism
OTO - NOTNLM
OT  - Metabolomics
OT  - Origin
OT  - Schisandra chinensis
EDAT- 2014/01/15 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/14 06:00
PHST- 2013/11/14 00:00 [received]
PHST- 2013/12/08 00:00 [revised]
PHST- 2013/12/22 00:00 [accepted]
PHST- 2014/01/14 06:00 [entrez]
PHST- 2014/01/15 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1002/jssc.201301242 [doi]
PST - ppublish
SO  - J Sep Sci. 2014 Mar;37(6):731-7. doi: 10.1002/jssc.201301242.