PMID- 2441807
OWN - NLM
STAT- MEDLINE
DCOM- 19871015
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 415
IP  - 1
DP  - 1987 Jul 7
TI  - Neurochemical differences in the superior cervical ganglion of the spontaneously 
      hypertensive rat stroke-prone variant.
PG  - 115-21
AB  - The localization and distribution of catecholamines, selected neuropeptides, and 
      the cyclic nucleotide second messengers has been determined in the superior 
      cervical ganglion of the stroke-prone variant of the spontaneously hypertensive 
      rat (SHR) and its normotensive Wistar-kyoto (WKY) control. Significant alteration 
      in the frequency of occurrence of dopaminergic small intensely fluorescent cell 
      clusters was seen in the stroke-prone variant of the SHR. The immunofluorescent 
      localization of cyclic AMP (cAMP) and cyclic GMP (cGMP) were also changed in the 
      stroke-prone variant, as was the immunofluorescent staining quantity of the 
      neuropeptides somatostatin and substance P. The morphological pattern of staining 
      for the various compounds in the normotensive control (WKY) was equivalent to the 
      Sprague-Dawley rat strain. The implications of the altered neurochemistry in the 
      superior cervical ganglion on the high blood pressure, and the predisposition for 
      stroke in this strain are discussed.
FAU - Ariano, M A
AU  - Ariano MA
FAU - Kenny, S L
AU  - Kenny SL
LA  - eng
GR  - NS 00867/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Catecholamines)
RN  - 0 (Neuropeptides)
RN  - 0 (Nucleotides, Cyclic)
RN  - 33507-63-0 (Substance P)
RN  - 51110-01-1 (Somatostatin)
RN  - E0399OZS9N (Cyclic AMP)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Animals
MH  - Catecholamines/*metabolism
MH  - Cerebrovascular Disorders/*metabolism
MH  - Cyclic AMP/metabolism
MH  - Cyclic GMP/analysis
MH  - Ganglia, Sympathetic/cytology/*metabolism/physiopathology
MH  - Hypertension/*metabolism
MH  - Neuropeptides/*metabolism
MH  - Nucleotides, Cyclic/*metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Somatostatin/metabolism
MH  - Substance P/metabolism
EDAT- 1987/07/07 00:00
MHDA- 1987/07/07 00:01
CRDT- 1987/07/07 00:00
PHST- 1987/07/07 00:00 [pubmed]
PHST- 1987/07/07 00:01 [medline]
PHST- 1987/07/07 00:00 [entrez]
AID - 0006-8993(87)90274-5 [pii]
AID - 10.1016/0006-8993(87)90274-5 [doi]
PST - ppublish
SO  - Brain Res. 1987 Jul 7;415(1):115-21. doi: 10.1016/0006-8993(87)90274-5.