PMID- 24418707
OWN - NLM
STAT- MEDLINE
DCOM- 20141013
LR  - 20191210
IS  - 1880-3989 (Electronic)
IS  - 0388-1350 (Linking)
VI  - 39
IP  - 1
DP  - 2014 Feb
TI  - Maternal MDMA administration in mice leads to neonatal growth delay.
PG  - 33-9
AB  - The psychoactive recreational drug 3,4-methylenedioxymethamphetamine (MDMA) is 
      widely abused. The fact that MDMA induces neurotoxic damage in serotonergic nerve 
      endings is well known. However, the effects of MDMA on pregnant and neonatal 
      animals remain unknown. Therefore, we studied the effects of gestational exposure 
      to MDMA on birth, growth, and behavior of pups. Female BALB/c mice were orally 
      administered either water (10 ml/kg) or MDMA (20 mg/10 ml/kg) from gestational 
      day 1 to postnatal day (P) 21. MDMA did not affect the birth rate, but the 
      survival rate of the pups significantly decreased. A significant reduction in 
      body weight gain was observed in pups from MDMA-administered dams during P3-P21. 
      Maternal MDMA treatment caused an attenuated cliff avoidance reaction and 
      decreased motor function in the pups, as determined by the wire hanging test. 
      These results suggest that MDMA treatment during pregnancy and lactation causes 
      growth retardation and dysfunction of motor neurons in mouse pups.
FAU - Kaizaki, Asuka
AU  - Kaizaki A
AD  - Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, 
      Showa University School of Pharmacy.
FAU - Tanaka, Sachiko
AU  - Tanaka S
FAU - Yoshida, Takemi
AU  - Yoshida T
FAU - Numazawa, Satoshi
AU  - Numazawa S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Illicit Drugs)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Body Weight/*drug effects
MH  - Female
MH  - Gestational Age
MH  - Growth and Development/*drug effects
MH  - *Illicit Drugs
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - *Maternal-Fetal Exchange
MH  - Mice
MH  - Motor Activity/drug effects
MH  - Motor Neurons/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & 
      dosage/metabolism/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Psychomotor Performance/drug effects
MH  - Reaction Time
MH  - Serotonergic Neurons/drug effects
EDAT- 2014/01/15 06:00
MHDA- 2014/10/14 06:00
CRDT- 2014/01/15 06:00
PHST- 2014/01/15 06:00 [entrez]
PHST- 2014/01/15 06:00 [pubmed]
PHST- 2014/10/14 06:00 [medline]
AID - DN/JST.JSTAGE/jts/39.33 [pii]
AID - 10.2131/jts.39.33 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2014 Feb;39(1):33-9. doi: 10.2131/jts.39.33.