PMID- 24418714
OWN - NLM
STAT- MEDLINE
DCOM- 20141013
LR  - 20190911
IS  - 1880-3989 (Electronic)
IS  - 0388-1350 (Linking)
VI  - 39
IP  - 1
DP  - 2014 Feb
TI  - Repeated dose and reproductive/developmental toxicity of perfluoroundecanoic acid 
      in rats.
PG  - 97-108
AB  - Perfluoroalkyl acids (PFAAs) are environmental contaminants that have received 
      attention because of their possible effects on wildlife and human health. In 
      order to obtain initial risk information on the toxicity of perfluoroundecanoic 
      acid (PFUA), we conducted a combined repeated dose toxicity study with the 
      reproduction/developmental toxicity screening test (OECD test guideline 422). 
      PFUA was administered by gavage to rats at 0 (vehicle: corn oil), 0.1, 0.3 or 1.0 
      mg/kg/day. At 1.0 mg/kg/day, body weight gain was inhibited in both sexes, and 
      there was a decrease in fibrinogen in both sexes and shortening of the activated 
      partial thromboplastin time in males. An increase in blood urea nitrogen and a 
      decrease in total protein in both sexes and increases in alkaline phosphatase and 
      alanine transaminase and a decrease in albumin in males were observed at 1.0 
      mg/kg/day. Liver weight was increased in males at 0.3 mg/kg/day and above and in 
      females at 1.0 mg/kg/day, and this change was observed after a recovery period. 
      In both sexes, centrilobular hypertrophy of hepatocytes was observed at 0.3 
      mg/kg/day and above and focal necrosis was observed at 1.0 mg/kg/day. In 
      reproductive/developmental toxicity, body weight of pups at birth was lowered and 
      body weight gain at 4 days after birth was inhibited at 1.0 mg/kg/day, while no 
      dose-related changes were found in the other parameters. Based on these findings, 
      the no observed adverse effect levels (NOAELs) for the repeated dose and 
      reproductive/developmental toxicity were considered to be 0.1 mg/kg/day and 0.3 
      mg/kg/day, respectively.
FAU - Takahashi, Mika
AU  - Takahashi M
AD  - Division of Risk Assessment, Biological Safety Research Center, National 
      Institute of Health Sciences.
FAU - Ishida, Shigeru
AU  - Ishida S
FAU - Hirata-Koizumi, Mutsuko
AU  - Hirata-Koizumi M
FAU - Ono, Atsushi
AU  - Ono A
FAU - Hirose, Akihiko
AU  - Hirose A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Air Pollutants)
RN  - 0 (Fatty Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (perfluoroundecanoic acid)
SB  - IM
MH  - *Air Pollutants
MH  - Animals
MH  - Body Weight/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Fatty Acids/*administration & dosage/*toxicity
MH  - Female
MH  - Fluorocarbons/*administration & dosage/*toxicity
MH  - Hepatocytes/*drug effects/pathology
MH  - Hypertrophy
MH  - Male
MH  - Necrosis
MH  - No-Observed-Adverse-Effect Level
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproduction/*drug effects
EDAT- 2014/01/15 06:00
MHDA- 2014/10/14 06:00
CRDT- 2014/01/15 06:00
PHST- 2014/01/15 06:00 [entrez]
PHST- 2014/01/15 06:00 [pubmed]
PHST- 2014/10/14 06:00 [medline]
AID - DN/JST.JSTAGE/jts/39.97 [pii]
AID - 10.2131/jts.39.97 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2014 Feb;39(1):97-108. doi: 10.2131/jts.39.97.