PMID- 2441910
OWN - NLM
STAT- MEDLINE
DCOM- 19871019
LR  - 20190918
IS  - 0730-0077 (Print)
IS  - 0730-0077 (Linking)
VI  - 9
IP  - 4
DP  - 1987
TI  - Augmented vascular responses to ouabain in SHRSP during salt loading.
PG  - 753-71
AB  - It is not known whether high salt diet alters the sarcolemmal Na-K pump activity 
      of resistance vessels in stroke-prone spontaneously hypertensive rats (SHRSP). We 
      examined hindquarters vascular responses to ouabain 10(-3) M in the isolated 
      hindquarters perfused with the Krebs-Henseleit solution in SHRSP and in 
      normotensive Wistar-Kyoto rats (WKY) after two weeks of either normal (0.3% NaCl) 
      or high (8% NaCl) salt diet. Salt loading increased arterial pressure (P less 
      than 0.05) and augmented ouabain-induced vasoconstriction (P less than 0.01) in 
      SHRSP. In WKY, salt loading did not alter arterial pressure or vascular responses 
      to ouabain. Neither hindquarters vascular resistance during maximal 
      vasodilatation produced by nitroprusside nor hindquarters vascular responses to 
      norepinephrine were different between the two groups of SHRSP, which suggested 
      that augmented response to ouabain in SHRSP on high salt diet could not be 
      explained by structural vascular changes. Vasodilatation by phentolamine during 
      maximal vasoconstriction induced by ouabain was also not different between two 
      groups of SHRSP, which suggested that ouabain-induced release of norepinephrine 
      from nerve endings was not different between the two groups of SHRSP. These 
      results suggest that salt loading might augment the sarcolemmal Na-K pump 
      activity of hindquarters resistance vessels in SHRSP but not in WKY. The 
      augmented sarcolemmal Na-K pump activity of resistance vessels may act against 
      salt-induced vasoconstriction in SHRSP.
FAU - Imaizumi, T
AU  - Imaizumi T
FAU - Takeshita, A
AU  - Takeshita A
FAU - Ashihara, T
AU  - Ashihara T
FAU - Yamamoto, K
AU  - Yamamoto K
FAU - Nakamura, M
AU  - Nakamura M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Exp Hypertens A
JT  - Clinical and experimental hypertension. Part A, Theory and practice
JID - 8207790
RN  - 0 (Ion Channels)
RN  - 169D1260KM (Nitroprusside)
RN  - 5ACL011P69 (Ouabain)
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Blood Vessels/*drug effects/physiopathology/ultrastructure
MH  - Diet
MH  - Hindlimb/blood supply
MH  - Hypertension/etiology/physiopathology
MH  - Ion Channels/metabolism
MH  - Male
MH  - Nitroprusside/pharmacology
MH  - Norepinephrine/pharmacology
MH  - Ouabain/*pharmacology
MH  - Potassium/metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Sarcolemma/metabolism
MH  - Sodium/*administration & dosage/adverse effects/metabolism
MH  - Vascular Resistance/drug effects
MH  - Vasoconstriction/drug effects
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.3109/10641968709161448 [doi]
PST - ppublish
SO  - Clin Exp Hypertens A. 1987;9(4):753-71. doi: 10.3109/10641968709161448.