PMID- 24419745
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20211021
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 37
IP  - 3
DP  - 2014 Jun
TI  - Xanthones from Securidaca inappendiculata exert significant therapeutic efficacy 
      on adjuvant-induced arthritis in mice.
PG  - 908-16
LID - 10.1007/s10753-014-9810-8 [doi]
AB  - The study was designed to investigate effects of the xanthones from Securidaca 
      inappendiculata on adjuvant-induced arthritis (AA) mice in vivo. Arthritis 
      severity was evaluated by arthritic score, body weight loss, paw circumference, 
      histological changes and hyperplasia of lymphatic tissues. Plasma samples were 
      collected for estimation of interleukin-1 (IL-1), tumor necrosis factor alpha 
      (TNF-alpha), monocyte chemotactic protein 1 (MCP-1) and vascular endothelial growth 
      factor (VEGF) using enzyme-linked immunosorbent assay method. The levels of 
      glutathione (GSH), malondialdehyde (MDA), N-acetyl glucosaminidase (NAG) and 
      sialic acid (SA) in liver were assessed by colorimetric method. Xanthones 
      significantly ameliorated the severity of AA indicated by the physical parameters 
      changes, and reverted the abnormal changes of MDA, GSH, NAG and SA in liver. 
      Levels of IL-1, TNF-alpha, MCP-1 and VEGF reduced dramatically meanwhile. The effects 
      of xanthones on AA were the outcome of the multitargets activities, and probably 
      associated with NF-kappaB signaling pathway.
FAU - Zuo, Jian
AU  - Zuo J
AD  - College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xian Lin Road, 
      Nanjing, China.
FAU - Xia, Yan
AU  - Xia Y
FAU - Li, Xiang
AU  - Li X
FAU - Chen, Jian-Wei
AU  - Chen JW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-1)
RN  - 0 (Plant Preparations)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Xanthones)
RN  - 0 (vascular endothelial growth factor A, mouse)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 3.2.1.52 (Acetylglucosaminidase)
RN  - GAN16C9B8O (Glutathione)
RN  - GZP2782OP0 (N-Acetylneuraminic Acid)
SB  - IM
MH  - Acetylglucosaminidase/metabolism
MH  - Animals
MH  - Arthritis, Experimental/*drug therapy
MH  - Chemokine CCL2/blood
MH  - Glutathione/metabolism
MH  - Hyperplasia/*drug therapy
MH  - Interleukin-1/blood
MH  - Liver/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Mice
MH  - Mice, Inbred DBA
MH  - N-Acetylneuraminic Acid/metabolism
MH  - Plant Preparations/*pharmacology
MH  - Securidaca/metabolism
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Vascular Endothelial Growth Factor A/blood
MH  - Xanthones/*pharmacology
EDAT- 2014/01/15 06:00
MHDA- 2015/06/16 06:00
CRDT- 2014/01/15 06:00
PHST- 2014/01/15 06:00 [entrez]
PHST- 2014/01/15 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
AID - 10.1007/s10753-014-9810-8 [doi]
PST - ppublish
SO  - Inflammation. 2014 Jun;37(3):908-16. doi: 10.1007/s10753-014-9810-8.