PMID- 24420336
OWN - NLM
STAT- MEDLINE
DCOM- 20141118
LR  - 20221207
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 61
IP  - 3
DP  - 2014
TI  - Association between skeletal muscle mass and insulin secretion in patients with 
      type 2 diabetes mellitus.
PG  - 281-7
AB  - Recent research has indicated a relationship between skeletal muscle mass and 
      insulin resistance in patients with type 2 diabetes mellitus (T2DM). However, no 
      study has examined the relationship between skeletal muscle mass and insulin 
      secretion in patients with Japanese T2DM. This study aimed to fill this research 
      gap by investigating the relationship between skeletal muscle mass and clinical 
      parameters of T2DM with special reference to the effect of sex or age on the 
      relationship. We examined 138 consecutive T2DM patients who presented at a single 
      center. Anthropomorphic measurement was conducted and skeletal muscle mass was 
      determined by bioelectrical impedance analysis for calculating skeletal muscle 
      index (SMI) as the ratio of appendicular muscle mass (AMM) to total body weight. 
      Fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) were levels, and 
      values of stimulated C-peptide immunoreactivity (CPR) were determined by glucagon 
      stimulation testing. Statistical analysis showed that AMM was negatively 
      correlated with age in T2DM patients, whereas SMI had no correlation with either 
      FPG or HbA1c levels. On the other hand, SMI was found to be negatively correlated 
      with the log-transformed stimulated CPR values in male patients <65 years (r = 
      -0.40, p < 0.05) and in female patients <65 years (r = -0.40, p < 0.05). The 
      results of multivariate analysis suggest a strong association between the 
      log-transformed stimulated CPR value and SMI. These findings indicate that 
      increased endogenous insulin secretion is associated with lower skeletal muscle 
      mass in T2DM patients who are <65 years of age.
FAU - Shishikura, Kanako
AU  - Shishikura K
AD  - Department of Internal Medicine (I), Osaka Medical College, Takatsuki 569-8686, 
      Japan.
FAU - Tanimoto, Keiji
AU  - Tanimoto K
FAU - Sakai, Satoshi
AU  - Sakai S
FAU - Tanimoto, Yoshimi
AU  - Tanimoto Y
FAU - Terasaki, Jungo
AU  - Terasaki J
FAU - Hanafusa, Toshiaki
AU  - Hanafusa T
LA  - eng
PT  - Journal Article
DEP - 20140110
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Blood Glucose
MH  - C-Peptide/blood
MH  - Diabetes Mellitus, Type 2/blood/*physiopathology
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Insulin/*metabolism
MH  - Insulin Resistance
MH  - Insulin Secretion
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*anatomy & histology
EDAT- 2014/01/15 06:00
MHDA- 2014/11/19 06:00
CRDT- 2014/01/15 06:00
PHST- 2014/01/15 06:00 [entrez]
PHST- 2014/01/15 06:00 [pubmed]
PHST- 2014/11/19 06:00 [medline]
AID - DN/JST.JSTAGE/endocrj/EJ13-0375 [pii]
AID - 10.1507/endocrj.ej13-0375 [doi]
PST - ppublish
SO  - Endocr J. 2014;61(3):281-7. doi: 10.1507/endocrj.ej13-0375. Epub 2014 Jan 10.