PMID- 2442328
OWN - NLM
STAT- MEDLINE
DCOM- 19871016
LR  - 20180330
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 117
IP  - 8
DP  - 1987 Aug
TI  - Alteration of pancreatic enzyme activities in small intestine of rats fed a high 
      fructose, low copper diet.
PG  - 1447-52
AB  - This study describes the progressive effects on pancreatic enzyme activities from 
      washings of the small intestine of rats fed diets containing either 62% starch 
      (S) or fructose (F), with 0.6 mg copper/kg diet (-Cu) or 6.0 mg copper/kg diet 
      (+Cu) from 21 to 61 d of age. Hepatic copper concentration of the 
      copper-deficient groups was 50% of that of the copper-supplemented groups. Body 
      and relative pancreatic weights were lower in the F-Cu dietary group than in any 
      other group. Relative liver weight was significantly higher in the fructose 
      dietary groups than in the starch dietary groups. There were significant 
      carbohydrate (CHO) X week and Cu X week interactions for luminal amylase 
      activities and the CHO X Cu X week interaction was significant for luminal lipase 
      and trypsin activities. The lowest enzyme activities were observed in the 
      F-Cu-fed rats. The CHO X week interaction was significant for chymotrypsin with 
      the lowest enzyme activities in the fructose-fed rats. It appears that high 
      dietary fructose and low dietary copper interact to produce greatly reduced 
      pancreatic enzyme activities in small intestinal washings. We speculate that 
      subsequent digestive and absorptive abnormalities during a period of rapid growth 
      may account for the severe morbidity and mortality in copper-deficient, 
      fructose-fed rats.
FAU - Lewis, C G
AU  - Lewis CG
FAU - Fields, M
AU  - Fields M
FAU - Craft, N
AU  - Craft N
FAU - Yang, C Y
AU  - Yang CY
FAU - Reiser, S
AU  - Reiser S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Dietary Carbohydrates)
RN  - 30237-26-4 (Fructose)
RN  - 789U1901C5 (Copper)
RN  - 9005-25-8 (Starch)
RN  - EC 3.1.1.3 (Lipase)
RN  - EC 3.2.1.- (Amylases)
RN  - EC 3.4.21.1 (Chymotrypsin)
RN  - EC 3.4.21.4 (Trypsin)
SB  - IM
MH  - Amylases/metabolism
MH  - Animals
MH  - Body Weight/drug effects
MH  - Chymotrypsin/metabolism
MH  - Copper/*deficiency/metabolism
MH  - Dietary Carbohydrates/administration & dosage/*pharmacology
MH  - Fructose/administration & dosage/*pharmacology
MH  - Intestine, Small/drug effects/*enzymology
MH  - Lipase/metabolism
MH  - Male
MH  - Pancreas/drug effects/*enzymology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Starch/pharmacology
MH  - Trypsin/metabolism
MH  - Weaning
EDAT- 1987/08/01 00:00
MHDA- 1987/08/01 00:01
CRDT- 1987/08/01 00:00
PHST- 1987/08/01 00:00 [pubmed]
PHST- 1987/08/01 00:01 [medline]
PHST- 1987/08/01 00:00 [entrez]
AID - 10.1093/jn/117.8.1447 [doi]
PST - ppublish
SO  - J Nutr. 1987 Aug;117(8):1447-52. doi: 10.1093/jn/117.8.1447.