PMID- 24423899 OWN - NLM STAT- MEDLINE DCOM- 20140421 LR - 20151119 IS - 1879-1913 (Electronic) IS - 0002-9149 (Linking) VI - 113 IP - 5 DP - 2014 Mar 1 TI - Findings of cardiac magnetic resonance imaging in asymptomatic myocardial ischemic disease in Takayasu arteritis. PG - 881-7 LID - S0002-9149(13)02390-4 [pii] LID - 10.1016/j.amjcard.2013.11.045 [doi] AB - Takayasu arteritis (TA) may affect myocardium and cause coronary stenosis. The aim of this study was to assess the prevalence and pattern of myocardial disease in patients with TA, using late gadolinium enhancement (LGE) of cardiac magnetic resonance imaging (CMRI). Twenty-seven consecutive patients with TA and 80 age- and gender-matched controls without known cardiovascular disease underwent CMRI. The prevalence of myocardial ischemic disease, as revealed by LGE, was compared between patients with TA and controls, and factors associated with myocardial disease were identified in patients with TA. Myocardial ischemic disease, as characterized by LGE on CMRI, was present in 7 (25.9%) of 27 patients with TA, and imaging with LGE showed a typical pattern of myocardial infarction in 6 patients (22.2%). Although both patients with TA and control subjects shared a similar risk of cardiovascular events, the prevalence of myocardial ischemia was >5x greater in patients with TA (p = 0.002 vs controls). No association was found between myocardial disease in patients with TA and cardiovascular atherosclerotic risk factors. The presence of myocardial scarring tended to be more closely associated with specific features of TA such as renovascular hypertension, older age at the onset of TA symptoms, male gender, aneurysmal dilatation, and Numano type V. In conclusion, finding of a significant and unexpectedly high prevalence of occult myocardial scarring in patients with TA indicates the usefulness of CMRI with LGE for the identification of occult myocardial disease in such patients. CI - Copyright (c) 2014 Elsevier Inc. All rights reserved. FAU - Comarmond, Cloe AU - Comarmond C AD - Department of Internal Medicine 2, Centre de Reference des Maladies Autoimmunes Rares, Assistance Publique-Hopitaux de Paris (AP-HP), Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France. FAU - Cluzel, Philippe AU - Cluzel P AD - Department of Cardiovascular Imaging and Interventional Radiology, Assistance Publique-Hopitaux de Paris (AP-HP), Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France. FAU - Toledano, Dan AU - Toledano D AD - Department of Cardiovascular Imaging and Interventional Radiology, Assistance Publique-Hopitaux de Paris (AP-HP), Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France. FAU - Costedoat-Chalumeau, Nathalie AU - Costedoat-Chalumeau N AD - Department of Internal Medicine 2, Centre de Reference des Maladies Autoimmunes Rares, Assistance Publique-Hopitaux de Paris (AP-HP), Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France. FAU - Isnard, Richard AU - Isnard R AD - Department of Cardiology, Assistance Publique-Hopitaux de Paris (AP-HP), Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France. FAU - Gaudric, Julien AU - Gaudric J AD - Department of Vascular Surgery, Assistance Publique-Hopitaux de Paris (AP-HP), Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France. FAU - Chiche, Laurent AU - Chiche L AD - Department of Vascular Surgery, Assistance Publique-Hopitaux de Paris (AP-HP), Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France. FAU - Koskas, Fabien AU - Koskas F AD - Department of Vascular Surgery, Assistance Publique-Hopitaux de Paris (AP-HP), Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France. FAU - Cacoub, Patrice AU - Cacoub P AD - Department of Internal Medicine 2, Centre de Reference des Maladies Autoimmunes Rares, Assistance Publique-Hopitaux de Paris (AP-HP), Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France. FAU - Saadoun, David AU - Saadoun D AD - Department of Internal Medicine 2, Centre de Reference des Maladies Autoimmunes Rares, Assistance Publique-Hopitaux de Paris (AP-HP), Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France. Electronic address: david.saadoun@psl.aphp.fr. LA - eng PT - Journal Article DEP - 20131212 PL - United States TA - Am J Cardiol JT - The American journal of cardiology JID - 0207277 RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Adult MH - Asymptomatic Diseases/*epidemiology MH - Cicatrix/pathology MH - Female MH - Gadolinium MH - Humans MH - Hypertension, Renovascular/epidemiology MH - Image Enhancement MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged MH - Myocardial Ischemia/*epidemiology/pathology MH - Myocardium/pathology MH - Prevalence MH - Risk Assessment MH - Takayasu Arteritis/*epidemiology EDAT- 2014/01/16 06:00 MHDA- 2014/04/22 06:00 CRDT- 2014/01/16 06:00 PHST- 2013/07/21 00:00 [received] PHST- 2013/11/07 00:00 [revised] PHST- 2013/11/07 00:00 [accepted] PHST- 2014/01/16 06:00 [entrez] PHST- 2014/01/16 06:00 [pubmed] PHST- 2014/04/22 06:00 [medline] AID - S0002-9149(13)02390-4 [pii] AID - 10.1016/j.amjcard.2013.11.045 [doi] PST - ppublish SO - Am J Cardiol. 2014 Mar 1;113(5):881-7. doi: 10.1016/j.amjcard.2013.11.045. Epub 2013 Dec 12.