PMID- 24424794
OWN - NLM
STAT- MEDLINE
DCOM- 20150608
LR  - 20211021
IS  - 1532-7558 (Electronic)
IS  - 1070-5503 (Linking)
VI  - 21
IP  - 6
DP  - 2014 Dec
TI  - Potentially modifiable correlates of functional status in patients with chronic 
      heart failure.
PG  - 956-60
LID - 10.1007/s12529-014-9385-7 [doi]
AB  - BACKGROUND: Chronic heart failure (CHF) patients suffer from multiple and 
      agonizing symptoms like shortness of breath and reduced functional status, the 
      latter of which is usually assessed using New York Heart Association (NYHA) 
      functional class. PURPOSE: In order to identify potentially modifiable factors of 
      reduced functional status in patients with CHF, we investigated somatic and 
      psychosocial correlates of NYHA functional class. We subsequently compared the 
      results to correlates of left ventricular ejection fraction (LVEF) as an 
      objective parameter of disease severity. METHODS: The cross-sectional study 
      (n = 314) was part of the German Heart Failure Network. Data were analysed using 
      a logistic regression modelling process. RESULTS: In the final regression model, 
      NYHA functional class was only significantly associated with depression (odds 
      ratio (OR) = 1.18; 95% confidence interval (CI) = 1.09-1.27) and multimorbidity 
      (OR = 1.17; 95% CI = 1.04-1.32). LVEF was associated with amino-terminal 
      pro-brain natriuretic peptide (NT-proBNP) (OR = 0.60; 95% CI = 0.44-0.82), 
      aetiology of CHF (OR = 2.08; 95% CI = 1.11-3.90), and smoking (OR = 2.21; 95% 
      CI = 1.25-3.91). CONCLUSIONS: Whereas LVEF was not related to depression, our 
      data revealed a close association between functional status (as assessed by NYHA 
      functional class) and depression in patients with CHF, even after adjusting for 
      cardiac and socio-demographic variables. Different forms of underlying causal 
      mechanisms could be suspected; it appears promising to further investigate this 
      specific interaction. In any event, pending further investigation, our results 
      underscore the need to examine CHF patients with respect to both somatic symptom 
      burden and potential depressive disorders.
FAU - Lossnitzer, Nicole
AU  - Lossnitzer N
AD  - Department of General Internal Medicine and Psychosomatics, Heidelberg University 
      Hospital, Heidelberg, Germany, Nicole_Lossnitzer@med.uni-heidelberg.de.
FAU - Wild, Beate
AU  - Wild B
FAU - Schultz, Jobst-Hendrik
AU  - Schultz JH
FAU - Frankenstein, Lutz
AU  - Frankenstein L
FAU - Haass, Markus
AU  - Haass M
FAU - Rauch, Bernhard
AU  - Rauch B
FAU - Lowe, Bernd
AU  - Lowe B
FAU - Katus, Hugo
AU  - Katus H
FAU - Herzog, Wolfgang
AU  - Herzog W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Behav Med
JT  - International journal of behavioral medicine
JID - 9421097
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Depression/*epidemiology
MH  - Female
MH  - Germany/epidemiology
MH  - Heart Failure/classification/*epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Severity of Illness Index
MH  - Young Adult
EDAT- 2014/01/16 06:00
MHDA- 2015/06/09 06:00
CRDT- 2014/01/16 06:00
PHST- 2014/01/16 06:00 [entrez]
PHST- 2014/01/16 06:00 [pubmed]
PHST- 2015/06/09 06:00 [medline]
AID - 10.1007/s12529-014-9385-7 [doi]
PST - ppublish
SO  - Int J Behav Med. 2014 Dec;21(6):956-60. doi: 10.1007/s12529-014-9385-7.