PMID- 24426241 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140115 LR - 20211021 IS - 0970-1915 (Print) IS - 0974-0422 (Electronic) IS - 0970-1915 (Linking) VI - 28 IP - 4 DP - 2013 Oct TI - Does melatonin ameliorate neurological changes associated with Alzheimer's disease in ovariectomized rat model? PG - 381-9 LID - 10.1007/s12291-012-0284-x [doi] AB - This study aimed to elucidate the mechanisms of melatonin to manage neurological damage in Alzheimer's disease (AD) induced in ovariectomized rats. Forty adult female rats were enrolled in our study and were classified as; gonad intact control, ovariectomized control group, ovariectomized rats received melatonin, ovariectomized rats injected with AlCl3 to induce AD and AD-induced rats treated with melatonin. Hydrogen peroxide (H2O2), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), B cell lymphoma 2 (Bcl-2), brain derived neurotrophic factor (BDNF), acetylcholinesterase (AchE) and acetylcholine (Ach) were estimated in the brain tissues of the different groups. Treatment of AD-induced rats with melatonin produced marked improvement in the most studied biomarkers which was confirmed by histological investigation of the brain. In Conclusion, melatonin significantly ameliorates the neurodegeneration characteristic of AD in experimental animal model due to its antioxidant, antiapoptotic, neurotrophic and anti-amyloidogenic activities. FAU - Ahmed, Hanaa H AU - Ahmed HH AD - Hormones Department, Medical Research Division, National Research Centre, Dokki, Cairo, 12622 Egypt. FAU - Estefan, Selim F AU - Estefan SF AD - Hormones Department, Medical Research Division, National Research Centre, Dokki, Cairo, 12622 Egypt. FAU - Mohamd, Ehab M AU - Mohamd EM AD - Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt. FAU - Farrag, Abd El-Razik H AU - Farrag Ael-R AD - Pathology Department, National Research Centre, Dokki, Cairo, Egypt. FAU - Salah, Rania S AU - Salah RS AD - Hormones Department, Medical Research Division, National Research Centre, Dokki, Cairo, 12622 Egypt. LA - eng PT - Journal Article DEP - 20121222 PL - India TA - Indian J Clin Biochem JT - Indian journal of clinical biochemistry : IJCB JID - 8708303 PMC - PMC3783909 OTO - NOTNLM OT - Alzheimer's disease OT - Anti-amyloidogenesis OT - Melatonin OT - Neurogenesis OT - Rats EDAT- 2014/01/16 06:00 MHDA- 2014/01/16 06:01 PMCR- 2014/10/01 CRDT- 2014/01/16 06:00 PHST- 2012/08/13 00:00 [received] PHST- 2012/11/21 00:00 [accepted] PHST- 2014/01/16 06:00 [entrez] PHST- 2014/01/16 06:00 [pubmed] PHST- 2014/01/16 06:01 [medline] PHST- 2014/10/01 00:00 [pmc-release] AID - 284 [pii] AID - 10.1007/s12291-012-0284-x [doi] PST - ppublish SO - Indian J Clin Biochem. 2013 Oct;28(4):381-9. doi: 10.1007/s12291-012-0284-x. Epub 2012 Dec 22.