PMID- 24426631 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140115 LR - 20211021 IS - 0972-2068 (Print) IS - 0973-9793 (Electronic) IS - 0973-9793 (Linking) VI - 75 IP - Suppl 1 DP - 2013 Jun TI - A death associated with possible propofol infusion syndrome. PG - 407-8 LID - 10.1007/s12262-012-0754-7 [doi] AB - Propofol, an intravenously administered, centrally acting sedative/hypnotic, is a popular medication for anesthesia and sedation due to rapid onset, controllability and short recovery time. Prolonged propofol infusions, (>48 h) with elevated doses (>67 mcg/kg/min) may result in a rare but fatal condition known as the Propofol Related Infusion Syndrome (PRIS). This is a case of severe metabolic acidosis and refractory hyperkalemia in a 53 year old female with polytrauma on a continuous propofol infusion that was associated with fatal outcome. FAU - Agrawal, Nikhil AU - Agrawal N AD - Trauma Fellow, State Trauma Unit, Royal Perth Hospital, Wellington Street, Perth, Western Australia. FAU - Rao, Sudhakar AU - Rao S AD - FRACS, State Director Trauma Services, Royal Perth Hospital, Wellington Street, Perth, Western Australia. FAU - Nair, Roshan AU - Nair R AD - MBBS, State Trauma Unit, Royal Perth Hospital, Wellington Street, Perth, Western Australia. LA - eng PT - Journal Article DEP - 20120922 PL - India TA - Indian J Surg JT - The Indian journal of surgery JID - 0373026 PMC - PMC3693369 OTO - NOTNLM OT - Head injury OT - Propofol infusion syndrome EDAT- 2014/01/16 06:00 MHDA- 2014/01/16 06:01 PMCR- 2014/06/01 CRDT- 2014/01/16 06:00 PHST- 2011/06/23 00:00 [received] PHST- 2012/09/11 00:00 [accepted] PHST- 2014/01/16 06:00 [entrez] PHST- 2014/01/16 06:00 [pubmed] PHST- 2014/01/16 06:01 [medline] PHST- 2014/06/01 00:00 [pmc-release] AID - 754 [pii] AID - 10.1007/s12262-012-0754-7 [doi] PST - ppublish SO - Indian J Surg. 2013 Jun;75(Suppl 1):407-8. doi: 10.1007/s12262-012-0754-7. Epub 2012 Sep 22.