PMID- 24426744
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140115
LR  - 20211021
IS  - 0975-7651 (Print)
IS  - 0976-6952 (Electronic)
IS  - 0975-7651 (Linking)
VI  - 4
IP  - 3
DP  - 2013 Sep
TI  - Wilms' tumor: single centre retrospective study from South India.
PG  - 301-4
LID - 10.1007/s13193-013-0248-5 [doi]
AB  - Wilms' tumor is the most common malignant renal tumor in paediatric age group, 
      and is classically managed by multimodal treatment which involves surgery, 
      radiotherapy and chemotherapy. The last few decades have seen a dramatic change 
      in the prognosis of this disease, which once was a uniformly lethal malignancy. 
      While there is plenty of data in world literature on the outcome of Wilms' tumor, 
      there is paucity of data from India. Hence, we conducted the present study to 
      analyze the outcome of Wilms' tumor at our institute. To study the 
      clinicopathologic profile and outcome of Wilms' tumor with NWTS (National Wilms' 
      Tumor Study Group) IV protocol. Sixty-one patients with histopathological proven 
      diagnosis of Wilms' tumor and had received treatment at our institute from Jan 
      2003 through Dec 2010 were included for analysis. Patients received treatment 
      based on NWTS IV protocol. Patients were analysed for overall survival and event 
      free survival and these outcomes were correlated with age, sex, stage at 
      presentation and histology. Favourable histology which included focal anaplasia 
      was found in 80.3 % while unfavourable histology was elicited in 19.7 % of the 
      cases. The estimated 5 year event-free survival was 83.3 % and overall survival 
      was 85.2 %. Tumour histology was the single most important factor predicting the 
      survival. Patients with childhood Wilms' still present very late in our setting, 
      this poses management challenges as large tumor are technically difficult to 
      deliver at surgery. Histology has a crucial role in outcome of this disease. With 
      multidisciplinary approach, similar survival rates to National Wilms' Tumor Study 
      Group seems to be achievable even in Indian scenario.
FAU - Guruprasad, B
AU  - Guruprasad B
AD  - Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Post 
      graduate hostel Room number 108, Dr M H Marigowda road, Bangalore, 560029 India.
FAU - Rohan, B
AU  - Rohan B
AD  - Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Post 
      graduate hostel Room number 108, Dr M H Marigowda road, Bangalore, 560029 India.
FAU - Kavitha, S
AU  - Kavitha S
AD  - Department of Paediatric Oncology, Kidwai Memorial Institute of Oncology, 
      Bangalore, India.
FAU - Madhumathi, D S
AU  - Madhumathi DS
AD  - Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India.
FAU - Lokanath, D
AU  - Lokanath D
AD  - Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Post 
      graduate hostel Room number 108, Dr M H Marigowda road, Bangalore, 560029 India.
FAU - Appaji, L
AU  - Appaji L
AD  - Department of Paediatric Oncology, Kidwai Memorial Institute of Oncology, 
      Bangalore, India.
LA  - eng
PT  - Journal Article
DEP - 20130615
PL  - India
TA  - Indian J Surg Oncol
JT  - Indian journal of surgical oncology
JID - 101532448
PMC - PMC3771043
OTO - NOTNLM
OT  - Chemotherapy
OT  - India
OT  - Survival
OT  - Wilms' tumor
EDAT- 2014/01/16 06:00
MHDA- 2014/01/16 06:01
PMCR- 2014/09/01
CRDT- 2014/01/16 06:00
PHST- 2012/10/09 00:00 [received]
PHST- 2013/05/31 00:00 [accepted]
PHST- 2014/01/16 06:00 [entrez]
PHST- 2014/01/16 06:00 [pubmed]
PHST- 2014/01/16 06:01 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - 248 [pii]
AID - 10.1007/s13193-013-0248-5 [doi]
PST - ppublish
SO  - Indian J Surg Oncol. 2013 Sep;4(3):301-4. doi: 10.1007/s13193-013-0248-5. Epub 
      2013 Jun 15.