PMID- 24427296
OWN - NLM
STAT- MEDLINE
DCOM- 20141017
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 1
DP  - 2014
TI  - Expression of obesity markers and Persistent Organic Pollutants levels in adipose 
      tissue of obese patients: reinforcing the obesogen hypothesis?
PG  - e84816
LID - 10.1371/journal.pone.0084816 [doi]
LID - e84816
AB  - INTRODUCTION: Persistent Organic Pollutants (POPs) accumulate in adipose tissue 
      and some are described to possess endocrine disrupting capacities. Therefore, it 
      is important to evaluate their effects on key endocrine pathways in adipose 
      tissue (AT), to further evaluate their potential role in metabolic pathologies 
      such as obesity. OBJECTIVES: THE AIM IS TWOFOLD: (i) evaluate gene expression 
      levels of obesity marker genes, i.e. the adipokines leptin (LEP), adiponectin 
      (ADIPOQ) and Tumor Necrosis Factor alpha (TNFalpha) and the nuclear receptor, Peroxisome 
      Proliferator Activated Receptor gamma (PPARgamma) in paired subcutaneous (SAT) and 
      visceral (VAT) AT of obese subjects (n = 50) and to relate these values to serum 
      concentrations of LEP and ADIPOQ (ii) evaluate the association of expression 
      levels of marker genes in AT and serum with POP concentrations in AT. RESULTS AND 
      CONCLUSIONS: Leptin and adiponectin levels in serum were positively correlated to 
      respectively expression levels of leptin in SAT and adiponectin in VAT. Our study 
      shows more significant correlations between gene expression of obesity marker 
      genes and POP concentrations in VAT compared to SAT. Since VAT is more important 
      than SAT in pathologies associated with obesity, this suggests that POPs are able 
      to influence the association between obesity and the development of associated 
      pathologies. Moreover, this finding reveals the importance of VAT when 
      investigating the obesogen hypothesis. Concerning PPARgamma expression in VAT, 
      negative correlations with polychlorinated biphenyls (PCBs) concentrations were 
      found in non T2D patients. LEP serum concentrations correlated with several PCBs 
      in women whereas in men no correlations were found. This strengthens the 
      potential importance of gender differences in obesity and within the obesogen 
      hypothesis.
FAU - Pereira-Fernandes, Anna
AU  - Pereira-Fernandes A
AD  - Systemic Physiological and Ecotoxicological Research (SPHERE), Department of 
      Biology, University of Antwerp, Antwerp, Belgium.
FAU - Dirinck, Eveline
AU  - Dirinck E
AD  - Department of Endocrinology, Diabetology and Metabolism, Antwerp University 
      Hospital, University of Antwerp, Edegem, Belgium.
FAU - Dirtu, Alin C
AU  - Dirtu AC
AD  - Toxicological Centre, University of Antwerp, Antwerp, Belgium.
FAU - Malarvannan, Govindan
AU  - Malarvannan G
AD  - Toxicological Centre, University of Antwerp, Antwerp, Belgium.
FAU - Covaci, Adrian
AU  - Covaci A
AD  - Toxicological Centre, University of Antwerp, Antwerp, Belgium.
FAU - Van Gaal, Luc
AU  - Van Gaal L
AD  - Department of Endocrinology, Diabetology and Metabolism, Antwerp University 
      Hospital, University of Antwerp, Edegem, Belgium.
FAU - Vanparys, Caroline
AU  - Vanparys C
AD  - Systemic Physiological and Ecotoxicological Research (SPHERE), Department of 
      Biology, University of Antwerp, Antwerp, Belgium.
FAU - Jorens, Philippe G
AU  - Jorens PG
AD  - Department of Clinical Pharmacology, Antwerp University Hospital, University of 
      Antwerp, Edegem, Belgium.
FAU - Blust, Ronny
AU  - Blust R
AD  - Systemic Physiological and Ecotoxicological Research (SPHERE), Department of 
      Biology, University of Antwerp, Antwerp, Belgium.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140110
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood/metabolism
MH  - Female
MH  - *Gene Expression
MH  - Humans
MH  - Intra-Abdominal Fat/metabolism
MH  - Male
MH  - Middle Aged
MH  - Obesity/*genetics/*metabolism
MH  - Subcutaneous Fat/metabolism
MH  - Young Adult
PMC - PMC3888404
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/01/16 06:00
MHDA- 2014/10/18 06:00
PMCR- 2014/01/10
CRDT- 2014/01/16 06:00
PHST- 2013/07/26 00:00 [received]
PHST- 2013/11/27 00:00 [accepted]
PHST- 2014/01/16 06:00 [entrez]
PHST- 2014/01/16 06:00 [pubmed]
PHST- 2014/10/18 06:00 [medline]
PHST- 2014/01/10 00:00 [pmc-release]
AID - PONE-D-13-30532 [pii]
AID - 10.1371/journal.pone.0084816 [doi]
PST - epublish
SO  - PLoS One. 2014 Jan 10;9(1):e84816. doi: 10.1371/journal.pone.0084816. eCollection 
      2014.