PMID- 24427345
OWN - NLM
STAT- MEDLINE
DCOM- 20140905
LR  - 20220408
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 7
IP  - 1
DP  - 2014
TI  - Upregulated TIMP-1 correlates with poor prognosis of laryngeal squamous cell 
      carcinoma.
PG  - 246-54
AB  - The tissue inhibitor of metalloproteinase-1 (TIMP-1) is an endogenous inhibitor 
      of matrix metalloproteinases and potential biomarker of various types of human 
      cancers. However, the association between TIMP-1 expression and the clinical 
      features of laryngeal squamous cell carcinoma (LSCC) is barely investigated. In 
      this study, one-step quantitative reverse transcription-polymerase chain reaction 
      and immunohistochemical staining with tissue microarrays were employed to 
      evaluate the relationship between TIMP-1 expression and the clinicopathological 
      characteristics of LSCC. Results showed that the TIMP-1 mRNA and protein 
      expression levels were significantly higher in LSCC than in the corresponding 
      non-cancerous tissues (p<0.05). TIMP-1 protein expression in LSCC was associated 
      with tumor differentiation (p=0.012) and overall survival (p=0.043). Kaplan-Meier 
      method and Cox multi-factor analysis suggested that high TIMP-1 expression 
      (p=0.008) and positive lymph node metastasis (p=0.029) were significantly 
      associated with the poor survival of patients with LSCC. These data indicated 
      that TIMP-1 may be identified as a prognostic marker of LSCC.
FAU - Ma, Jun
AU  - Ma J
AD  - Department of Otolaryngology-Head and Neck Surgery, Yiji Shan Hospital, The First 
      Affiliated Hospital of Wannan Medical College No. 92 Zheshan Xi Road, Wuhu 
      241000, China.
FAU - Wang, Jun
AU  - Wang J
AD  - Department of Hematology and Oncology, Jiangsu Province Geriatric Institute No. 
      30 Luojia Road, Nanjing 210029, China.
FAU - Fan, Weifei
AU  - Fan W
AD  - Department of Hematology and Oncology, Jiangsu Province Geriatric Institute No. 
      30 Luojia Road, Nanjing 210029, China.
FAU - Pu, Xiaolin
AU  - Pu X
AD  - Department of Hematology and Oncology, Jiangsu Province Geriatric Institute No. 
      30 Luojia Road, Nanjing 210029, China.
FAU - Zhang, Dawei
AU  - Zhang D
AD  - Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated 
      Hospital of Nanjing Medical University No. 121 Jiang Jia Yuan, Nanjing 210011, 
      China.
FAU - Fan, Chou
AU  - Fan C
AD  - Department of Otolaryngology-Head and Neck Surgery, Yiji Shan Hospital, The First 
      Affiliated Hospital of Wannan Medical College No. 92 Zheshan Xi Road, Wuhu 
      241000, China.
FAU - Xiong, Lin
AU  - Xiong L
AD  - Department of Pathology, The Second Affiliated Hospital of Nanjing Medical 
      University No. 121 Jiang Jia Yuan, Nanjing 210011, China.
FAU - Zhu, Huijun
AU  - Zhu H
AD  - Department of Pathology and Laboratory Medicine, Nantong University Affiliated 
      Hospital No. 20 Xisi Road, Nantong 226001, China.
FAU - Xu, Ning
AU  - Xu N
AD  - Department of Pathology, Nanjing Medical University No. 140 Hanzhong Road, 
      Nanjing 210029, China.
FAU - Chen, Renjie
AU  - Chen R
AD  - Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated 
      Hospital of Nanjing Medical University No. 121 Jiang Jia Yuan, Nanjing 210011, 
      China.
FAU - Liu, Shaofeng
AU  - Liu S
AD  - Department of Otolaryngology-Head and Neck Surgery, Yiji Shan Hospital, The First 
      Affiliated Hospital of Wannan Medical College No. 92 Zheshan Xi Road, Wuhu 
      241000, China.
LA  - eng
PT  - Journal Article
DEP - 20131215
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (TIMP1 protein, human)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Lymphatic Metastasis/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tissue Array Analysis
MH  - Tissue Inhibitor of Metalloproteinase-1/analysis/*biosynthesis
MH  - Up-Regulation
PMC - PMC3885479
OTO - NOTNLM
OT  - LSCC
OT  - TIMP-1
OT  - immunohistochemistry
OT  - prognosis
OT  - qPCR
EDAT- 2014/01/16 06:00
MHDA- 2014/09/06 06:00
PMCR- 2013/12/15
CRDT- 2014/01/16 06:00
PHST- 2013/11/14 00:00 [received]
PHST- 2013/12/12 00:00 [accepted]
PHST- 2014/01/16 06:00 [entrez]
PHST- 2014/01/16 06:00 [pubmed]
PHST- 2014/09/06 06:00 [medline]
PHST- 2013/12/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2013 Dec 15;7(1):246-54. eCollection 2014.