PMID- 24428874
OWN - NLM
STAT- MEDLINE
DCOM- 20150112
LR  - 20151119
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 17
IP  - 4
DP  - 2014 May
TI  - The relationship between plasma homocysteine level and HLA-B51 in patients with 
      Behcet's disease: a case-control study.
PG  - 466-70
LID - 10.1111/1756-185X.12271 [doi]
AB  - BACKGROUND: Various coagulation disorders have been reported to explain 
      hypercoagulability state in Behcet's disease (BD). A possible negative 
      association between human leukocyte antigen (HLA)-B51 and increased homocysteine 
      level has been suggested in a previous report from Iranian patients with BD. The 
      aim of this study was to find any possible relationship between plasma 
      homocysteine levels and HLA-B51. METHODS: In a case-control study, BD patients 
      (fulfilling the new International Criteria for BD) and controls (who had similar 
      clinical symptoms but BD was clinically excluded in them) were included. Mean 
      plasma homocysteine levels measured by enzyme-linked immunosorbent assay in 
      HLA-B51 positive and negative individuals both in patients and controls were 
      compared by t-test, Mann-Whitney test and analysis of variance (F-test). RESULTS: 
      Ninety-six BD patients and 152 controls were recruited. There was no significant 
      difference between HLA-B51 positive and negative individuals either in the mean 
      plasma homocysteine levels (13.59 +/- 9.03 vs. 12.95 +/- 4.98 mumol/L, P = 0.514), or 
      in the prevalence of hyperhomocysteinemia (17% vs. 21.4%, P = 0.504). This was 
      true both for BD and control groups. In HLA-B51 positive and negative BD 
      patients, mean plasma homocysteine levels were 14.29 +/- 12.02 and 12.62 +/- 4.79 
      mumol/L, respectively (P = 0.33), and the prevalence of hyperhomocysteinemia was 
      20.8% versus 19.5% (P = 0.55). In the control group, the mean plasma homocysteine 
      levels in HLA-B51 positive and negative individuals were 12.85 +/- 4.28 and 13.14 +/- 
      5.10 mumol/L, respectively (P = 0.794), and the prevalence of hyperhomocysteinemia 
      was 13% versus 22.1% (P = 0.23). The difference was non-significant regarding sex 
      (P > 0.71) and disease activity (P > 0.31). CONCLUSION: In contrast to our 
      previous report, we found no relationship between plasma homocysteine levels and 
      HLA-B51 in this study, either in BD or in the control group.
CI  - (c) 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing 
      Asia Pty Ltd.
FAU - Shadmanfar, Soraya
AU  - Shadmanfar S
AD  - Rheumatology Department, Baqyiatallah University of Medical Sciences, 
      Baghiatallah Hospital, Tehran, Iran; Behcet's Disease Unit, Rheumatology Research 
      Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Shahram, Farhad
AU  - Shahram F
FAU - Nadji, Abdolhadi
AU  - Nadji A
FAU - Akhlaghi, Maassoumeh
AU  - Akhlaghi M
FAU - Faezi, Seyedeh T
AU  - Faezi ST
FAU - Sadeghi-Abdollahi, Bahar
AU  - Sadeghi-Abdollahi B
FAU - Faridar, Alireza
AU  - Faridar A
FAU - Madanchi, Nima
AU  - Madanchi N
FAU - Davatchi, Fereydoun
AU  - Davatchi F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140116
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (Biomarkers)
RN  - 0 (HLA-B51 Antigen)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Behcet Syndrome/*blood/diagnosis/epidemiology/*immunology
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HLA-B51 Antigen/*blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/diagnosis/epidemiology
MH  - Iran/epidemiology
MH  - Male
MH  - Prevalence
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Behcet's disease
OT  - HLA-B51
OT  - homocysteine
OT  - thrombosis
EDAT- 2014/01/17 06:00
MHDA- 2015/01/13 06:00
CRDT- 2014/01/17 06:00
PHST- 2014/01/17 06:00 [entrez]
PHST- 2014/01/17 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.1111/1756-185X.12271 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2014 May;17(4):466-70. doi: 10.1111/1756-185X.12271. Epub 2014 
      Jan 16.