PMID- 24431149
OWN - NLM
STAT- MEDLINE
DCOM- 20141113
LR  - 20160511
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 4
IP  - 4
DP  - 2014 Apr
TI  - Prevalence of antigen-specific immunoglobulin E on mucosal brush biopsy of the 
      inferior turbinates in patients with nonallergic rhinitis.
PG  - 292-7
LID - 10.1002/alr.21281 [doi]
AB  - BACKGROUND: This study investigates the prevalence of local, antigen-specific 
      immunoglobulin E (IgE) from mucosal brush biopsy (MBB) of the inferior turbinates 
      in people diagnosed with chronic, idiopathic, nonallergic rhinitis (NAR) based on 
      negative skin and/or in vitro testing. METHODS: A standard cytology brush was 
      used to harvest epithelial cells from the inferior turbinates of 20 adults. These 
      cells were then processed and tested for the presence of total and 
      antigen-specific IgE to 9 common aeroallergens using immunofluorescence. The 
      relationships between detectable IgE and quality of life (QOL), self-reported 
      seasonal symptoms and season of specimen collection were determined. RESULTS: 
      Antigen-specific IgE for at least 1 antigen was detected on MBB in all of 20 
      (100%) study participants with a mean of approximately 3 sensitizations per 
      participant. IgE to cockroach was present in 18 of 20 (90%) participants. There 
      was no significant association noted between QOL scores or self-reported seasonal 
      symptoms and the presence of specific IgE to any of the study antigens, although 
      the presence of white oak and ragweed IgE was significantly higher in patients 
      tested during the pollen season. CONCLUSION: This study demonstrated that, using 
      MBB of the inferior turbinates, antigen-specific IgE to at least 1 airborne 
      allergen is detectable in 100% of the idiopathic, NAR study population. This rate 
      of sensitization is notably higher than previous reports, suggesting that the 
      prevalence of atopic disease in the general population may be higher than current 
      estimates. Testing for local sensitization should be considered as part of the 
      complete evaluation for atopic disease.
CI  - (c) 2014 The Authors. International Forum of Allergy & Rhinology published by Wiley 
      Periodicals, Inc., on behalf of ARS-AAOA, LLC.
FAU - Reisacher, William R
AU  - Reisacher WR
AD  - Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical 
      College, New York, NY.
FAU - Bremberg, Maria G
AU  - Bremberg MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140115
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Allergens)
RN  - 0 (Insect Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - Animals
MH  - Biopsy
MH  - Cockroaches/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Insect Proteins/immunology
MH  - Male
MH  - Microvilli/pathology
MH  - Middle Aged
MH  - Quality of Life
MH  - Rhinitis/blood/*immunology/pathology
MH  - Self Report
MH  - Turbinates/pathology
MH  - Young Adult
OTO - NOTNLM
OT  - IgE
OT  - allergy testing
OT  - inferior turbinate
OT  - mucosal brush biopsy
OT  - nonallergic rhinitis
EDAT- 2014/01/17 06:00
MHDA- 2014/11/14 06:00
CRDT- 2014/01/17 06:00
PHST- 2012/09/06 00:00 [received]
PHST- 2013/11/10 00:00 [revised]
PHST- 2013/12/07 00:00 [accepted]
PHST- 2014/01/17 06:00 [entrez]
PHST- 2014/01/17 06:00 [pubmed]
PHST- 2014/11/14 06:00 [medline]
AID - 10.1002/alr.21281 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2014 Apr;4(4):292-7. doi: 10.1002/alr.21281. Epub 2014 
      Jan 15.