PMID- 24431239
OWN - NLM
STAT- MEDLINE
DCOM- 20150416
LR  - 20160511
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 4
IP  - 5
DP  - 2014 May
TI  - Active smoking status in chronic rhinosinusitis is associated with higher serum 
      markers of inflammation and lower serum eosinophilia.
PG  - 347-52
LID - 10.1002/alr.21289 [doi]
AB  - BACKGROUND: Smoking negatively affects postoperative evolution in patients with 
      chronic rhinosinusitis (CRS); however, the mechanism remains incompletely 
      described. In the lung, smoking increases expression of proinflammatory genes and 
      is associated with an elevation of inflammatory serum markers. Our objective is 
      to determine the impact of smoking on these biomarkers in CRS. METHODS: Two 
      existing populations of patients previously phenotyped for genetic association 
      studies (206 patients with refractory CRS and 408 patients with CRS and nasal 
      polyposis) were stratified according to self-reported smoking status and 
      available serum biomarkers (complete blood count [CBC], total immunoglobulin E 
      [IgE]). Asthma and bacterial cultures were evaluated. RESULTS: Active smoking was 
      low in both groups (genetics of chronic rhinosinusitis 1 [GCRS1]: 11.2%; genetics 
      of chronic rhinosinusitis 2 [GCRS2]: 9.4%). Total white blood cell (WBC) count 
      was significantly higher in active smokers than in those who had never smoked and 
      ex-smokers. Serum eosinophilia and prevalence of self-reported asthma was lower 
      in active smokers than never-smokers. In the GCRS2 population, 
      endoscopically-collected cultures trended toward a lower recovery rate of 
      Staphylococcus aureus in smokers (p = 0.07). Never-smokers and ex-smokers had 
      similar levels of WBCs and eosinophils. CONCLUSION: Our study reveals that active 
      tobacco smoking is associated with increases in markers of systemic inflammation 
      in patients with CRS. The proinflammatory effect of smoking seems not only to act 
      locally on sinus mucosa as previously described, but may also influence levels of 
      inflammatory biomarkers systemically, suggesting that smoking-induced changes 
      have profound implications for health. Nevertheless, these changes may be 
      potentially reversible; thus smoking cessation in CRS patients is strongly 
      advised, and may have an impact on response of CRS to therapy.
CI  - (c) 2014 ARS-AAOA, LLC.
FAU - Berania, Ilyes
AU  - Berania I
AD  - Department of Otolaryngology, Hotel-Dieu Hospital, Centre de Recherche du Centre 
      Hospitalier de l'Universite de Montreal (CRCHUM), Montreal, QC, Canada.
FAU - Endam, Leandra Mfuna
AU  - Endam LM
FAU - Filali-Mouhim, Abdelali
AU  - Filali-Mouhim A
FAU - Boisvert, Pierre
AU  - Boisvert P
FAU - Boulet, Louis-Philippe
AU  - Boulet LP
FAU - Bosse, Yohan
AU  - Bosse Y
FAU - Desrosiers, Martin
AU  - Desrosiers M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140115
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adult
MH  - Asthma/*epidemiology
MH  - Chronic Disease
MH  - Eosinophils/immunology
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/metabolism
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Rhinitis/*epidemiology
MH  - Sinusitis/*epidemiology
MH  - Smoking/adverse effects/*epidemiology
MH  - Staphylococcal Infections/*epidemiology
MH  - Staphylococcus aureus/*physiology
OTO - NOTNLM
OT  - Staphylococcus aureus
OT  - asthma
OT  - biomarkers
OT  - chronic rhinosinusitis
OT  - inflammation
OT  - smoking
EDAT- 2014/01/17 06:00
MHDA- 2015/04/17 06:00
CRDT- 2014/01/17 06:00
PHST- 2013/09/13 00:00 [received]
PHST- 2013/11/17 00:00 [revised]
PHST- 2013/12/12 00:00 [accepted]
PHST- 2014/01/17 06:00 [entrez]
PHST- 2014/01/17 06:00 [pubmed]
PHST- 2015/04/17 06:00 [medline]
AID - 10.1002/alr.21289 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2014 May;4(5):347-52. doi: 10.1002/alr.21289. Epub 2014 
      Jan 15.