PMID- 24432017
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140116
LR  - 20211021
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 4
DP  - 2014 Jan 7
TI  - Non-Myeloid Cells are Major Contributors to Innate Immune Responses via 
      Production of Monocyte Chemoattractant Protein-1/CCL2.
PG  - 482
LID - 10.3389/fimmu.2013.00482 [doi]
LID - 482
AB  - Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a chemokine regulating the 
      recruitment of monocytes into sites of inflammation and cancer. MCP-1 can be 
      produced by a variety of cell types, such as macrophages, neutrophils, 
      fibroblasts, endothelial cells, and epithelial cells. Notably, macrophages 
      produce high levels of MCP-1 in response to proinflammatory stimuli in vitro, 
      leading to the hypothesis that macrophages are the major source of MCP-1 during 
      inflammatory responses in vivo. In stark contrast to the hypothesis, however, 
      there was no significant reduction in MCP-1 protein or the number of infiltrating 
      macrophages in the peritoneal inflammatory exudates of myeloid cell-specific 
      MCP-1-deficient mice in response to i.p injection of thioglycollate or zymosan A. 
      Furthermore, injection of LPS into skin air pouch also had no effect on local 
      MCP-1 production in myeloid-specific MCP-1-deficient mice. Finally, 
      myeloid-specific MCP-1-deficiency did not reduce MCP-1 mRNA expression or 
      macrophage infiltration in LPS-induced lung injury. These results indicate that 
      non-myeloid cells, in response to a variety of stimulants, play a previously 
      unappreciated role in innate immune responses as the primary source of MCP-1.
FAU - Yoshimura, Teizo
AU  - Yoshimura T
AD  - Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center 
      for Cancer Research, National Cancer Institute , Frederick, MD , USA.
FAU - Galligan, Carole
AU  - Galligan C
AD  - Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center 
      for Cancer Research, National Cancer Institute , Frederick, MD , USA.
FAU - Takahashi, Munehisa
AU  - Takahashi M
AD  - Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center 
      for Cancer Research, National Cancer Institute , Frederick, MD , USA.
FAU - Chen, Keqiang
AU  - Chen K
AD  - Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center 
      for Cancer Research, National Cancer Institute , Frederick, MD , USA.
FAU - Liu, Mingyong
AU  - Liu M
AD  - Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center 
      for Cancer Research, National Cancer Institute , Frederick, MD , USA.
FAU - Tessarollo, Lino
AU  - Tessarollo L
AD  - Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer 
      Institute , Frederick, MD , USA.
FAU - Wang, Ji Ming
AU  - Wang JM
AD  - Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center 
      for Cancer Research, National Cancer Institute , Frederick, MD , USA.
LA  - eng
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20140107
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3882876
OTO - NOTNLM
OT  - chemokines
OT  - gene knockout mice
OT  - inflammation
OT  - innate immunity
OT  - myeloid cells
EDAT- 2014/01/17 06:00
MHDA- 2014/01/17 06:01
PMCR- 2013/01/01
CRDT- 2014/01/17 06:00
PHST- 2013/11/06 00:00 [received]
PHST- 2013/12/09 00:00 [accepted]
PHST- 2014/01/17 06:00 [entrez]
PHST- 2014/01/17 06:00 [pubmed]
PHST- 2014/01/17 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2013.00482 [doi]
PST - epublish
SO  - Front Immunol. 2014 Jan 7;4:482. doi: 10.3389/fimmu.2013.00482. eCollection 2014 
      Jan 7.