PMID- 24432020 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140624 LR - 20211021 IS - 1664-3224 (Print) IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 4 DP - 2014 Jan 6 TI - Therapeutic implications of immunogenic cell death in human cancer. PG - 503 LID - 10.3389/fimmu.2013.00503 [doi] LID - 503 AB - Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers. FAU - Palombo, Fabio AU - Palombo F AD - Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma , Rome , Italy. FAU - Focaccetti, Chiara AU - Focaccetti C AD - Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma , Rome , Italy. FAU - Barnaba, Vincenzo AU - Barnaba V AD - Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma , Rome , Italy ; Istituto Pasteur - Fondazione Cenci Bolognetti , Rome , Italy. LA - eng PT - Journal Article PT - Review DEP - 20140106 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 PMC - PMC3880935 OTO - NOTNLM OT - chemotherapy OT - dendritic cells, T cells OT - immunogenic cell death OT - tumor antigens EDAT- 2014/01/17 06:00 MHDA- 2014/01/17 06:01 PMCR- 2013/01/01 CRDT- 2014/01/17 06:00 PHST- 2013/10/24 00:00 [received] PHST- 2013/12/20 00:00 [accepted] PHST- 2014/01/17 06:00 [entrez] PHST- 2014/01/17 06:00 [pubmed] PHST- 2014/01/17 06:01 [medline] PHST- 2013/01/01 00:00 [pmc-release] AID - 10.3389/fimmu.2013.00503 [doi] PST - epublish SO - Front Immunol. 2014 Jan 6;4:503. doi: 10.3389/fimmu.2013.00503. eCollection 2014 Jan 6.