PMID- 24432383
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20231115
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 36
IP  - 12
DP  - 2013
TI  - Asiatic acid from Potentilla chinensis attenuate ethanol-induced hepatic injury 
      via suppression of oxidative stress and Kupffer cell activation.
PG  - 1980-9
AB  - This study examined the effect of Asiatic acid from Potentilla chinensis (AAPC) 
      on chronic ethanol-induced hepatic injury. Rats underwent intragastric 
      administration of ethanol (5.0-9.0 g/kg) once a day for 12 weeks. A subset of 
      rats were also intragastrically treated with AAPC (2, 4 or 8 mg/kg) once a day. 
      In the end, AAPC treatment significantly protected against ethanol-induced liver 
      injury, as evidenced by the decrease in serum alanine and aspartate 
      aminotransferases levels and the attenuation of histopathological changes in 
      rats. Additionally, AAPC significantly decreased blood alcohol and acetaldehyde 
      concentrations by enhancing alcohol dehydrogenase and aldehyde dehydrogenase 
      activities. Mechanistically, studies showed that AAPC remarkably alleviated the 
      formations of malondialdehyde and myeloperoxidase, restored impaired 
      antioxidants, including superoxide dismutase, glutathione peroxidase, glutathione 
      reductase and catalase, and inhibited cytochrome P450 (CYP)2E1 activity. 
      Moreover, the over-expression of cytokines, such as tumor necrosis factor 
      (TNF)-alpha, interleukin (IL)-1beta, inducible nitric oxide synthase (iNOS) and 
      cyclooxygenase-2 (COX-2), the elevated plasma endotoxin level and the 
      up-regulated Toll-like receptor 4 (TLR4), CD14 and myeloid differentiation factor 
      88 (MyD88) as well as nuclear factor-kappaB were also suppressed by AAPC in 
      ethanol-intoxicated rats. In conclusion, the protective effect of AAPC on 
      ethanol-induced hepatotoxicity was mainly due to its ability to attenuate 
      oxidative stress and inhibit Kupffer cell activation by decreasing the level of 
      plasma endotoxin and the expression of TLR4, CD14 and MyD88.
FAU - Wei, Jinbin
AU  - Wei J
FAU - Huang, Quanfang
AU  - Huang Q
FAU - Huang, Renbin
AU  - Huang R
FAU - Chen, Yongxing
AU  - Chen Y
FAU - Lv, Shujuan
AU  - Lv S
FAU - Wei, Ling
AU  - Wei L
FAU - Liang, Chunhong
AU  - Liang C
FAU - Liang, Shuang
AU  - Liang S
FAU - Zhuo, Lang
AU  - Zhuo L
FAU - Lin, Xing
AU  - Lin X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Endotoxins)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Myd88 protein, rat)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (NF-kappa B)
RN  - 0 (Pentacyclic Triterpenes)
RN  - 0 (Tlr4 protein, rat)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 3K9958V90M (Ethanol)
RN  - 9PA5A687X5 (asiatic acid)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.14.13.- (Cytochrome P-450 CYP2E1)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - GO1N1ZPR3B (Acetaldehyde)
SB  - IM
RIN - Biol Pharm Bull. 2023;46(11):1647. PMID: 37914370
MH  - Acetaldehyde/blood
MH  - Animals
MH  - Catalase/metabolism
MH  - Chemical and Drug Induced Liver Injury/*drug therapy/metabolism/pathology
MH  - Cytochrome P-450 CYP2E1/metabolism
MH  - Endotoxins/blood
MH  - Ethanol/blood/toxicity
MH  - Glutathione Peroxidase/metabolism
MH  - Glutathione Reductase/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Kupffer Cells/drug effects/metabolism
MH  - Lipopolysaccharide Receptors/metabolism
MH  - Liver/drug effects/metabolism/pathology
MH  - Male
MH  - Myeloid Differentiation Factor 88/metabolism
MH  - NF-kappa B/metabolism
MH  - Oxidative Stress/drug effects
MH  - Pentacyclic Triterpenes/pharmacology/*therapeutic use
MH  - Peroxidase/metabolism
MH  - Phytotherapy
MH  - *Potentilla
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/metabolism
MH  - Toll-Like Receptor 4/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2014/01/17 06:00
MHDA- 2014/07/16 06:00
CRDT- 2014/01/17 06:00
PHST- 2014/01/17 06:00 [entrez]
PHST- 2014/01/17 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1248/bpb.b13-00634 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2013;36(12):1980-9. doi: 10.1248/bpb.b13-00634.