PMID- 24432597
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20151119
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 85
IP  - 11
DP  - 2013
TI  - [C-reactive protein as a marker of the severity of an infectious process in acute 
      myeloid leukemia patients with neutropenia].
PG  - 34-40
AB  - AIM: To determine C-reactive protein (CRP) levels as diagnostic markers of 
      infection in acute myeloid leukemia (AML) patients with neutropenia. SUBJECTS AND 
      METHODS: Sixty-three AML patients (28 men and 35 women) aged 20 to 77 years 
      (median 50 years) were examined. According to the French-American-British (FAB) 
      classification, the types of AML were as follows: M0 (n = 3), M1 (n = 9), M2 (n = 
      35), M4 (n = 10), and M5 (n = 6). All the patients had chemotherapy-associated 
      neutropenia (granulocytes, less than 0.5.10(9)/l). In different treatment steps, 
      all the patients developed infectious complications (the study analyzed the data 
      of 86 cases). RESULTS: In patients with localized infections (such as mucositis, 
      abscess, pneumonia, etc.) or fever of unknown origin (FUO), the levels of CRP 
      were not statistically significant different, but were significantly higher than 
      in those without infectious complications. The concentrations of CRP did not 
      differ in patients with systemic inflammatory response syndrome (SIRS) and in 
      those with sepsis. At the same time, the level of CRP in systemic infection 
      (SIRS, sepsis) was significantly higher than that in localized infection (p < 
      0.001). In patients with neutropenia, the median CRP levels were as follows: 7 
      mg/l (range 0-37; 95% reference interval (RI) 0 to 32) for those without 
      infection 56 mg/l (range 13-104; 95% RI 17 to 104) for those with localized 
      infection or FUO; and 168 mg/l (range 103-399; 95% RI 105 to 362) for those with 
      systemic infection. CONCLUSION: CRP is a marker of the severity of an infectious 
      process in AML patients with neutropenia. The increase of its level more than 32 
      mg/l serves a valid criterion for the presence of infection and more than 105 
      mg/l does for that of a systemic inflammatory response in these patients.
FAU - Vladimirova, S G
AU  - Vladimirova SG
FAU - Tarasova, L N
AU  - Tarasova LN
FAU - Sokol'skaia, O Iu
AU  - Sokol'skaia OIu
FAU - Cherepanova, V V
AU  - Cherepanova VV
LA  - rus
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*metabolism
MH  - Female
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*blood/complications/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Neutropenia/*blood/complications
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Systemic Inflammatory Response Syndrome/*blood/diagnosis/etiology
MH  - Young Adult
EDAT- 2014/01/18 06:00
MHDA- 2014/02/22 06:00
CRDT- 2014/01/18 06:00
PHST- 2014/01/18 06:00 [entrez]
PHST- 2014/01/18 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
PST - ppublish
SO  - Ter Arkh. 2013;85(11):34-40.